Detailed information NTG1142026

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: DQL12_RS11665
• Genome accession: NZ_LS483450
• Coordinates: 2154404..2154529 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain 4041STDY6583227
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2149404..2159529

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL12_RS12615	-	2149764..2151367 (-)	1604	Protein_2142	YhgE/Pip family protein	-
DQL12_RS11640	-	2151525..2152067 (+)	543	WP_050123485.1	TetR/AcrR family transcriptional regulator	-
DQL12_RS11655	comE	2152309..2153061 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
DQL12_RS11660	comD/comD2	2153058..2154383 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
DQL12_RS11665	comC/comC2	2154404..2154529 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
DQL12_RS11675	rlmH	2154811..2155290 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL12_RS11680	htrA	2155473..2156654 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
DQL12_RS11685	spo0J	2156712..2157470 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=1142026 DQL12_RS11665 WP_000799686.1 2154404..2154529(-) (comC/comC2) [Streptococcus pneumoniae strain 4041STDY6583227]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=1142026 DQL12_RS11665 WP_000799686.1 2154404..2154529(-) (comC/comC2) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561