Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   DQL12_RS09235 Genome accession   NZ_LS483450
Coordinates   1721108..1721767 (+) Length   219 a.a.
NCBI ID   WP_000565021.1    Uniprot ID   C1C962
Organism   Streptococcus pneumoniae strain 4041STDY6583227     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1714924..1741448 1721108..1721767 within 0


Gene organization within MGE regions


Location: 1714924..1741448
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL12_RS09195 - 1714924..1715556 (-) 633 Protein_1729 SUMF1/EgtB/PvdO family nonheme iron enzyme -
  DQL12_RS09200 - 1715540..1716058 (-) 519 Protein_1730 PTS sugar transporter subunit IIC -
  DQL12_RS09205 - 1716068..1716385 (-) 318 WP_001005886.1 PTS lactose/cellobiose transporter subunit IIA -
  DQL12_RS09210 - 1716402..1716719 (-) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  DQL12_RS09215 - 1716734..1717630 (-) 897 WP_050255459.1 PEP phosphonomutase -
  DQL12_RS09220 - 1717633..1718906 (-) 1274 Protein_1734 PTS sugar transporter subunit IIC -
  DQL12_RS09225 - 1719186..1720364 (+) 1179 WP_000175876.1 ROK family transcriptional regulator -
  DQL12_RS09230 - 1720592..1721038 (-) 447 WP_000155418.1 GNAT family N-acetyltransferase -
  DQL12_RS09235 cclA/cilC 1721108..1721767 (+) 660 WP_000565021.1 prepilin peptidase Machinery gene
  DQL12_RS09240 - 1721819..1722970 (-) 1152 WP_000481756.1 XRE family transcriptional regulator -
  DQL12_RS09245 - 1722985..1723716 (-) 732 WP_000934017.1 hypothetical protein -
  DQL12_RS09250 - 1723936..1724046 (+) 111 Protein_1740 prepilin peptidase -
  DQL12_RS09255 trpA 1724018..1724794 (-) 777 WP_001127049.1 tryptophan synthase subunit alpha -
  DQL12_RS09260 trpB 1724787..1726010 (-) 1224 WP_000331287.1 tryptophan synthase subunit beta -
  DQL12_RS09265 - 1725988..1726587 (-) 600 WP_000169889.1 phosphoribosylanthranilate isomerase -
  DQL12_RS09270 trpC 1726574..1727341 (-) 768 WP_000076535.1 indole-3-glycerol phosphate synthase TrpC -
  DQL12_RS09275 trpD 1727338..1728342 (-) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  DQL12_RS09280 - 1728353..1728919 (-) 567 WP_000601927.1 aminodeoxychorismate/anthranilate synthase component II -
  DQL12_RS09285 trpE 1728916..1730277 (-) 1362 WP_050217637.1 anthranilate synthase component I -
  DQL12_RS12340 - 1730650..1730856 (-) 207 WP_000693078.1 hypothetical protein -
  DQL12_RS09295 - 1731464..1732465 (-) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  DQL12_RS12590 - 1732573..1732940 (-) 368 Protein_1750 hypothetical protein -
  DQL12_RS09305 - 1733036..1733746 (-) 711 WP_000127552.1 MgtC/SapB family protein -
  DQL12_RS09310 - 1733749..1735440 (-) 1692 WP_001216185.1 ABC transporter permease -
  DQL12_RS09315 - 1735452..1736462 (-) 1011 WP_000589142.1 ABC transporter ATP-binding protein -
  DQL12_RS09320 - 1736566..1737633 (-) 1068 WP_000738375.1 extracellular solute-binding protein -
  DQL12_RS09325 - 1737658..1738317 (-) 660 WP_000793809.1 DUF1868 domain-containing protein -
  DQL12_RS09330 - 1738480..1738794 (-) 315 Protein_1756 GDP-mannose 4,6-dehydratase -
  DQL12_RS09335 - 1739042..1739338 (-) 297 WP_000239024.1 hypothetical protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24854.98 Da        Isoelectric Point: 7.9575

>NTDB_id=1141991 DQL12_RS09235 WP_000565021.1 1721108..1721767(+) (cclA/cilC) [Streptococcus pneumoniae strain 4041STDY6583227]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=1141991 DQL12_RS09235 WP_000565021.1 1721108..1721767(+) (cclA/cilC) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTAGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1C962

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae D39

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae R6

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae TIGR4

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

93.151

100

0.932
  cclA/cilC Streptococcus mitis NCTC 12261

87.671

100

0.877

Multiple sequence alignment