Detailed information NTG1140976

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQN75_RS00330
• Genome accession: NZ_LS483420
• Coordinates: 52881..53792 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC13739
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47881..58792

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN75_RS00310 (NCTC13739_00062)	purE	48467..48958 (+)	492	WP_111684462.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQN75_RS00315 (NCTC13739_00063)	purK	48945..50018 (+)	1074	WP_172454106.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQN75_RS00320 (NCTC13739_00064)	-	50020..51438 (+)	1419	WP_011888524.1	hypothetical protein	-
DQN75_RS00325 (NCTC13739_00065)	purB	51458..52750 (+)	1293	WP_038433842.1	adenylosuccinate lyase	-
DQN75_RS00330 (NCTC13739_00066)	comR	52881..53792 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQN75_RS09305 (NCTC13739_00067)	comS	53876..53971 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQN75_RS00335 (NCTC13739_00068)	ruvB	54018..55016 (+)	999	WP_111684466.1	Holliday junction branch migration DNA helicase RuvB	-
DQN75_RS00340 (NCTC13739_00069)	-	55154..55591 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQN75_RS00345 (NCTC13739_00070)	-	55614..56015 (+)	402	WP_111684468.1	MORN repeat-containing protein	-
DQN75_RS00350 (NCTC13739_00071)	-	56012..57787 (+)	1776	WP_111684470.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1140976 DQN75_RS00330 WP_002986681.1 52881..53792(+) (comR) [Streptococcus pyogenes strain NCTC13739]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1140976 DQN75_RS00330 WP_002986681.1 52881..53792(+) (comR) [Streptococcus pyogenes strain NCTC13739]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462