Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DQN54_RS02665 Genome accession   NZ_LS483417
Coordinates   484287..485024 (+) Length   245 a.a.
NCBI ID   WP_001219122.1    Uniprot ID   A0A0I5XJR5
Organism   Streptococcus pneumoniae strain NCTC11902     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 479287..490024
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN54_RS02635 (NCTC11902_00489) - 480618..480905 (-) 288 WP_000777761.1 hypothetical protein -
  DQN54_RS02640 (NCTC11902_00490) - 480915..481325 (-) 411 WP_001112361.1 HIT family protein -
  DQN54_RS02645 (NCTC11902_00491) pptA 481393..482124 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  DQN54_RS02650 (NCTC11902_00492) - 482121..483170 (+) 1050 WP_000653767.1 ABC transporter permease -
  DQN54_RS02655 (NCTC11902_00493) - 483338..483667 (-) 330 WP_000132572.1 hypothetical protein -
  DQN54_RS02660 (NCTC11902_00494) - 483944..484282 (+) 339 WP_000682135.1 LytTR family DNA-binding domain-containing protein -
  DQN54_RS02665 (NCTC11902_00495) comE/blpR 484287..485024 (+) 738 WP_001219122.1 response regulator transcription factor Regulator
  DQN54_RS02670 (NCTC11902_00496) - 485038..486378 (+) 1341 WP_001017626.1 sensor histidine kinase -
  DQN54_RS02675 (NCTC11902_00497) blpC 486420..486575 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  DQN54_RS02680 (NCTC11902_00498) - 486632..487993 (-) 1362 WP_001069091.1 bacteriocin secretion accessory protein -
  DQN54_RS02685 (NCTC11902_00499) comA/nlmT 488004..489680 (-) 1677 WP_196299874.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28766.95 Da        Isoelectric Point: 6.4140

>NTDB_id=1140859 DQN54_RS02665 WP_001219122.1 484287..485024(+) (comE/blpR) [Streptococcus pneumoniae strain NCTC11902]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1140859 DQN54_RS02665 WP_001219122.1 484287..485024(+) (comE/blpR) [Streptococcus pneumoniae strain NCTC11902]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I5XJR5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38

Multiple sequence alignment