Detailed information NTG1140733

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQN44_RS00340
• Genome accession: NZ_LS483414
• Coordinates: 55502..56413 (+)
• Length: 303 a.a.
• NCBI ID: WP_111705970.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC13736
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 50502..61413

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN44_RS00320 (NCTC13736_00064)	purE	50798..51289 (+)	492	WP_030127619.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQN44_RS00325 (NCTC13736_00065)	purK	51276..52349 (+)	1074	WP_030127620.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQN44_RS00330 (NCTC13736_00066)	-	52370..53710 (+)	1341	WP_030127621.1	hypothetical protein	-
DQN44_RS00335 (NCTC13736_00067)	purB	54078..55370 (+)	1293	WP_030127622.1	adenylosuccinate lyase	-
DQN44_RS00340 (NCTC13736_00068)	comR	55502..56413 (+)	912	WP_111705970.1	transcriptional regulator Rgg4/ComR	Regulator
DQN44_RS10205 (NCTC13736_00069)	comS	56497..56592 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQN44_RS00345 (NCTC13736_00070)	ruvB	56639..57637 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQN44_RS00350 (NCTC13736_00071)	-	57775..58212 (+)	438	WP_030127623.1	low molecular weight protein-tyrosine-phosphatase	-
DQN44_RS00355 (NCTC13736_00072)	-	58235..58636 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DQN44_RS00360 (NCTC13736_00073)	-	58633..60408 (+)	1776	WP_021733211.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35756.29 Da
• Isoelectric Point: 4.5201

>NTDB_id=1140733 DQN44_RS00340 WP_111705970.1 55502..56413(+) (comR) [Streptococcus pyogenes strain NCTC13736]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKNVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1140733 DQN44_RS00340 WP_111705970.1 55502..56413(+) (comR) [Streptococcus pyogenes strain NCTC13736]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAAATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.333	99.01	0.578
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.027	96.37	0.492
comR	Streptococcus mutans UA159	46.026	99.67	0.459