Detailed information NTG1140502

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: DQN33_RS03140
• Genome accession: NZ_LS483408
• Coordinates: 593824..594546 (+)
• Length: 240 a.a.
• NCBI ID: WP_012658092.1
• Uniprot ID: B9DRI3
• Organism: Streptococcus uberis strain NCTC4674
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 588824..599546

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN33_RS03110 (NCTC4674_00641)	-	588915..589412 (+)	498	WP_012658085.1	YkgJ family cysteine cluster protein	-
DQN33_RS03115 (NCTC4674_00642)	-	589450..590394 (-)	945	WP_111673122.1	peptidoglycan recognition family protein	-
DQN33_RS10105 (NCTC4674_00644)	-	590441..591121 (+)	681	WP_145960778.1	NAD(P)-dependent oxidoreductase	-
DQN33_RS03125 (NCTC4674_00645)	-	591180..591995 (-)	816	WP_012658088.1	TIGR03943 family putative permease subunit	-
DQN33_RS03130 (NCTC4674_00646)	-	591992..592900 (-)	909	WP_012658089.1	permease	-
DQN33_RS10155 (NCTC4674_00647)	-	592952..593098 (-)	147	WP_012658090.1	SPJ_0845 family protein	-
DQN33_RS03135 (NCTC4674_00648)	-	593290..593673 (+)	384	WP_012658091.1	VOC family protein	-
DQN33_RS03140 (NCTC4674_00649)	vicR	593824..594546 (+)	723	WP_012658092.1	response regulator transcription factor	Regulator
DQN33_RS03145	pnpS	594530..595854 (+)	1325	Protein_565	two-component system histidine kinase PnpS	-
DQN33_RS03150 (NCTC4674_00652)	-	596027..596908 (+)	882	WP_012658094.1	substrate-binding domain-containing protein	-
DQN33_RS03155 (NCTC4674_00653)	pstC	596974..597837 (+)	864	WP_012658095.1	phosphate ABC transporter permease subunit PstC	-
DQN33_RS03160 (NCTC4674_00654)	pstA	597830..598645 (+)	816	WP_012658096.1	phosphate ABC transporter permease PstA	-
DQN33_RS03165 (NCTC4674_00655)	pstB	598647..599399 (+)	753	WP_012658097.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 240 a.a.
• Molecular weight: 28359.83 Da
• Isoelectric Point: 6.3173

>NTDB_id=1140502 DQN33_RS03140 WP_012658092.1 593824..594546(+) (vicR) [Streptococcus uberis strain NCTC4674]
MKKHILLVDDEEHILRLLDYHLKKEGYETDLAEDGRTALKLAESEHYDFILLDIMLPQLDGIEVCKRIRSKGNKTPIMMV
SAKGEEFDKVLALELGADDYMTKPFSPRELIARLKAILRRTEKTEEEDTTGLPEEYWTINHLVIYPERHEVYKNQKLLNL
TPKEFELLLYLVKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDDPKKPVFIKTIRGYGYKFKELKDETKS

Nucleotide

• Length: 723 bp

>NTDB_id=1140502 DQN33_RS03140 WP_012658092.1 593824..594546(+) (vicR) [Streptococcus uberis strain NCTC4674]
ATGAAAAAACATATTTTATTAGTCGATGATGAAGAACATATCTTACGTCTATTAGATTATCATTTGAAAAAAGAAGGTTA
TGAGACAGATCTTGCTGAGGATGGTAGGACAGCGCTAAAACTAGCAGAATCTGAACATTATGATTTTATTTTATTAGACA
TTATGTTGCCACAATTAGATGGTATTGAAGTCTGTAAAAGAATCCGTTCCAAGGGAAACAAGACTCCAATTATGATGGTA
TCTGCTAAAGGGGAGGAGTTTGATAAAGTACTAGCACTTGAACTTGGTGCTGATGATTATATGACAAAACCTTTTAGTCC
TAGAGAGTTAATTGCCAGATTAAAGGCTATTTTAAGACGAACTGAAAAAACTGAAGAAGAGGATACTACAGGTTTACCAG
AAGAATATTGGACTATTAATCACTTGGTTATTTATCCTGAAAGGCATGAAGTTTATAAAAATCAAAAGTTACTAAATCTA
ACACCGAAAGAATTTGAACTCTTACTTTATCTAGTCAAACATCCTAATATGACTCTAACAAGAGAACGACTCTTAGAACG
GATATGGGGTTATGATTTTGGACAAGAAACCCGTTTGGTAGATGTCCATATTGGTAAGTTGAGAGAAAAAATTGAGGATG
ATCCTAAAAAACCAGTGTTTATCAAAACGATTCGTGGATATGGTTATAAATTTAAGGAGCTAAAGGATGAAACAAAATCT
TAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-114)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (158-231)

3D structure

• AlphaFold DB: B9DRI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	52.137	97.5	0.508
micA	Streptococcus pneumoniae Cp1015	49.573	97.5	0.483
covR	Lactococcus lactis subsp. lactis strain DGCC12653	42.308	97.5	0.413
covR	Streptococcus salivarius strain HSISS4	40.343	97.083	0.392