Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   DQN33_RS03075 Genome accession   NZ_LS483408
Coordinates   579212..580570 (+) Length   452 a.a.
NCBI ID   WP_012658078.1    Uniprot ID   B9DRG9
Organism   Streptococcus uberis strain NCTC4674     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 574212..585570
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN33_RS03045 (NCTC4674_00628) - 574229..575236 (+) 1008 WP_111673119.1 DUF3114 domain-containing protein -
  DQN33_RS03050 (NCTC4674_00629) - 575267..575914 (-) 648 WP_012658074.1 amino acid ABC transporter permease -
  DQN33_RS03055 (NCTC4674_00630) - 575930..576631 (-) 702 WP_012658075.1 amino acid ABC transporter permease -
  DQN33_RS03060 (NCTC4674_00631) - 576646..577461 (-) 816 WP_012658076.1 transporter substrate-binding domain-containing protein -
  DQN33_RS03065 (NCTC4674_00632) - 577475..578254 (-) 780 WP_012658077.1 amino acid ABC transporter ATP-binding protein -
  DQN33_RS03070 (NCTC4674_00633) vicR 578509..579219 (+) 711 WP_015912156.1 response regulator YycF Regulator
  DQN33_RS03075 (NCTC4674_00634) vicK 579212..580570 (+) 1359 WP_012658078.1 cell wall metabolism sensor histidine kinase VicK Regulator
  DQN33_RS03080 (NCTC4674_00635) vicX 580574..581383 (+) 810 WP_046393354.1 MBL fold metallo-hydrolase Regulator
  DQN33_RS03085 (NCTC4674_00636) rnc 581542..582234 (+) 693 WP_012658080.1 ribonuclease III -

Sequence

Protein


Download         Length: 452 a.a.        Molecular weight: 51569.95 Da        Isoelectric Point: 4.8795

>NTDB_id=1140500 DQN33_RS03075 WP_012658078.1 579212..580570(+) (vicK) [Streptococcus uberis strain NCTC4674]
MTENLIGNLSLFELSILLLLIFVAAYFIYLAVRDYRNAKIIRQMSHKIRDLINGRYTDEINEKADIELIELSEQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRTGQIMMINETAQKQLNISKEEALLMNITDLLGQDTPYTYRELVSKTPI
VTLNRRDETGEFITLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTALAVEMTNFTAFMTSILNRFDLVRNQNTVSGKSYEIIRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKIRVKMKTTDSQLIISISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIVKQHNGFIWAKSDYGKGSTFTIVLPYEKDVVAGTDDEWEDDID

Nucleotide


Download         Length: 1359 bp        

>NTDB_id=1140500 DQN33_RS03075 WP_012658078.1 579212..580570(+) (vicK) [Streptococcus uberis strain NCTC4674]
ATGACTGAGAACCTAATCGGAAATTTATCGTTATTCGAACTTTCAATCTTATTATTACTTATTTTTGTTGCTGCATATTT
TATTTATTTAGCAGTTCGTGACTATCGAAATGCCAAAATTATTCGGCAAATGAGTCATAAAATCCGTGACCTAATCAATG
GTCGTTACACGGATGAAATCAATGAAAAAGCTGATATTGAGCTCATAGAACTTTCTGAGCAACTCAATGATTTATCGGAT
GTCTTTCGATTGACCCATGAAAATCTTGCCCAGGAAAAAAATCGCTTAGCCAGTATTTTGGCCTACATGAGTGATGGGGT
TTTGGCAACAGACCGAACTGGTCAAATCATGATGATTAACGAAACCGCCCAAAAACAATTGAATATTTCGAAAGAAGAAG
CCCTTTTAATGAATATCACGGATTTGTTAGGGCAAGACACTCCCTATACCTACCGGGAATTGGTTTCCAAAACACCGATT
GTTACCTTGAATAGACGCGATGAGACTGGTGAATTTATCACCCTCAGGTTGCGCTTTGCCTTGAATAGAAGAGAAAGTGG
CTTTATTTCGGGGCTCGTTGTCGTCCTACATGACACTACCGAACAGGAAAAAGAAGAACGTGAGCGTCGCCTCTTTGTTT
CGAATGTTAGTCACGAATTAAGAACGCCATTGACATCAGTCAAATCCTATTTGGAAGCCCTGGATGAGGGTGCCTTAAAA
GAAGATATCGCACCAAGTTTCATCAAAGTTTCATTAGATGAAACCAATCGGATGATGCGAATGATTTCGGACTTGTTAAA
CCTGTCTCGTATTGATAACCAAGTCACAGCTCTAGCGGTTGAAATGACCAATTTCACAGCCTTTATGACTTCTATACTAA
ATCGTTTTGATTTAGTGAGAAACCAAAATACAGTTTCAGGGAAAAGCTATGAAATTATACGAGACTATCCTATTACTTCT
GTTTGGCTAGAAATTGACAATGATAAAATGACACAAGTCATTGAAAACATTTTAAATAATGCTATCAAATATTCACCTGA
TGGTGGTAAAATTCGTGTTAAGATGAAAACAACAGATAGTCAATTGATTATCTCTATTTCGGATCAAGGATTAGGAATTC
CAAAGAAAGATCTTCCTTTGATTTTTGACCGATTTTATCGGGTGGATAAAGCACGCAGTCGTGCACAAGGTGGAACAGGT
TTAGGACTTGCCATTGCTAAAGAAATTGTAAAACAACATAATGGTTTTATATGGGCAAAAAGTGACTATGGCAAAGGCTC
GACCTTTACAATTGTATTGCCATATGAAAAAGATGTTGTTGCAGGAACAGATGATGAATGGGAGGATGATATTGACTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-436)

PAS fold (PAS)

(95-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B9DRG9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

73.608

91.372

0.673
  micB Streptococcus pneumoniae Cp1015

65.882

94.027

0.619

Multiple sequence alignment