Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQN33_RS02135 Genome accession   NZ_LS483408
Coordinates   418818..419504 (+) Length   228 a.a.
NCBI ID   WP_012657914.1    Uniprot ID   B9DTP8
Organism   Streptococcus uberis strain NCTC4674     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 413818..424504
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN33_RS02110 (NCTC4674_00435) ktrB 414041..415432 (-) 1392 WP_269441091.1 potassium uptake transporter channel subunit KtrB -
  DQN33_RS02115 (NCTC4674_00436) rsmG 415504..416217 (-) 714 WP_012657909.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQN33_RS02120 (NCTC4674_00437) - 416364..416921 (+) 558 WP_012657910.1 LemA family protein -
  DQN33_RS02125 (NCTC4674_00438) htpX 416956..417849 (+) 894 WP_012657911.1 zinc metalloprotease HtpX -
  DQN33_RS02130 (NCTC4674_00439) - 418062..418595 (+) 534 WP_012657912.1 YceD family protein -
  DQN33_RS02135 (NCTC4674_00440) covR 418818..419504 (+) 687 WP_012657914.1 two-component system response regulator CovR Regulator
  DQN33_RS02140 (NCTC4674_00441) - 419508..421010 (+) 1503 WP_111673075.1 ATP-binding protein -
  DQN33_RS02145 (NCTC4674_00442) nrdR 421173..421667 (+) 495 WP_012657916.1 transcriptional regulator NrdR -
  DQN33_RS02150 (NCTC4674_00443) - 421651..422847 (+) 1197 WP_046387903.1 DnaD domain protein -
  DQN33_RS02155 (NCTC4674_00444) dnaI 422848..423750 (+) 903 WP_111673076.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26623.61 Da        Isoelectric Point: 4.6541

>NTDB_id=1140494 DQN33_RS02135 WP_012657914.1 418818..419504(+) (covR) [Streptococcus uberis strain NCTC4674]
MTKKILIVEDEKNLARFVSLELQHEGYEVTVEVNGREGLETALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIETEKKAPNQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMSNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDMPGRESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1140494 DQN33_RS02135 WP_012657914.1 418818..419504(+) (covR) [Streptococcus uberis strain NCTC4674]
ATGACAAAGAAAATTTTAATCGTTGAAGATGAGAAAAATCTTGCGAGATTTGTATCTTTAGAATTACAACATGAAGGTTA
TGAAGTAACAGTCGAGGTAAATGGGCGTGAAGGTTTAGAAACGGCTCTTGAAAAAGACTTTGATTTAATCCTTTTAGATT
TAATGTTACCTGAAATGGATGGTTTTGAAGTGACACGTCGCTTACAGACTGAGAAAACAACCTATATCATGATGATGACT
GCACGTGATTCTATCATGGATGTCGTGGCAGGTTTAGACCGTGGTGCGGATGATTATATTGTTAAACCATTTGCCATTGA
AGAGTTATTAGCACGTATCAGAGCGATTTTCCGTCGTCAAGACATTGAAACAGAGAAGAAAGCTCCCAATCAAGGAATCT
ATCGTGATTTAGTTTTAAATCCACAAAATCGTTCAGTCAACCGTGGTGATGATGAAATTTCATTAACAAAACGTGAATAT
GATTTGTTAAATATTCTTATGTCAAATATGAACCGTGTTATGACACGTGAAGAATTATTATCAAACGTTTGGAAATATGA
CGAAGCAGTGGAAACAAATGTTGTTGATGTCTATATTCGTTACCTTCGTGGAAAAATTGACATGCCTGGAAGAGAGTCAT
ACATTCAAACAGTTCGTGGAATGGGATACGTAATTCGCGAGAAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B9DTP8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

83.406

100

0.838
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.723

100

0.443
  micA Streptococcus pneumoniae Cp1015

43.478

100

0.439

Multiple sequence alignment