Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM80_RS01475 Genome accession   NZ_LS483399
Coordinates   275588..276274 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8227     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 270588..281274
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM80_RS01450 (NCTC8227_00285) ktrB 270730..272106 (-) 1377 WP_032459877.1 potassium uptake transporter channel subunit KtrB -
  DQM80_RS01455 (NCTC8227_00286) rsmG 272191..272904 (-) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM80_RS01460 (NCTC8227_00287) - 273054..273611 (+) 558 WP_002985956.1 LemA family protein -
  DQM80_RS01465 (NCTC8227_00288) htpX 273658..274554 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQM80_RS01470 (NCTC8227_00289) - 274788..275321 (+) 534 WP_011054200.1 YceD family protein -
  DQM80_RS01475 (NCTC8227_00290) covR 275588..276274 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQM80_RS01480 (NCTC8227_00291) covS 276280..277781 (+) 1502 Protein_245 two-component system sensor histidine kinase CovS -
  DQM80_RS01485 (NCTC8227_00292) nrdR 277996..278490 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQM80_RS01490 (NCTC8227_00293) - 278474..279649 (+) 1176 WP_111701790.1 replication initiation and membrane attachment family protein -
  DQM80_RS01495 (NCTC8227_00294) dnaI 279650..280552 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1140220 DQM80_RS01475 WP_002991052.1 275588..276274(+) (covR) [Streptococcus pyogenes strain NCTC8227]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1140220 DQM80_RS01475 WP_002991052.1 275588..276274(+) (covR) [Streptococcus pyogenes strain NCTC8227]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment