Detailed information NTG1140161

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: DQM95_RS03355
• Genome accession: NZ_LS483397
• Coordinates: 588217..588939 (+)
• Length: 240 a.a.
• NCBI ID: WP_012658092.1
• Uniprot ID: B9DRI3
• Organism: Streptococcus uberis strain NCTC3858
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 583217..593939

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM95_RS03325 (NCTC3858_00674)	-	583283..583780 (+)	498	WP_012658085.1	YkgJ family cysteine cluster protein	-
DQM95_RS03330 (NCTC3858_00675)	-	583818..584831 (-)	1014	WP_230080762.1	peptidoglycan recognition family protein	-
DQM95_RS03335 (NCTC3858_00676)	-	584855..585514 (+)	660	WP_037592354.1	NAD(P)-dependent oxidoreductase	-
DQM95_RS03340 (NCTC3858_00677)	-	585573..586388 (-)	816	WP_037592353.1	TIGR03943 family putative permease subunit	-
DQM95_RS03345 (NCTC3858_00678)	-	586385..587293 (-)	909	WP_037592352.1	permease	-
DQM95_RS10055 (NCTC3858_00679)	-	587345..587491 (-)	147	WP_012658090.1	SPJ_0845 family protein	-
DQM95_RS03350 (NCTC3858_00680)	-	587683..588066 (+)	384	WP_012658091.1	VOC family protein	-
DQM95_RS03355 (NCTC3858_00681)	vicR	588217..588939 (+)	723	WP_012658092.1	response regulator transcription factor	Regulator
DQM95_RS03360 (NCTC3858_00682)	pnpS	588923..590248 (+)	1326	WP_037592351.1	two-component system histidine kinase PnpS	-
DQM95_RS03365 (NCTC3858_00683)	-	590421..591302 (+)	882	WP_012658094.1	substrate-binding domain-containing protein	-
DQM95_RS03370 (NCTC3858_00684)	pstC	591368..592231 (+)	864	WP_012658095.1	phosphate ABC transporter permease subunit PstC	-
DQM95_RS03375 (NCTC3858_00685)	pstA	592224..593039 (+)	816	WP_012658096.1	phosphate ABC transporter permease PstA	-
DQM95_RS03380 (NCTC3858_00686)	pstB	593041..593793 (+)	753	WP_037592350.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 240 a.a.
• Molecular weight: 28359.83 Da
• Isoelectric Point: 6.3173

>NTDB_id=1140161 DQM95_RS03355 WP_012658092.1 588217..588939(+) (vicR) [Streptococcus uberis strain NCTC3858]
MKKHILLVDDEEHILRLLDYHLKKEGYETDLAEDGRTALKLAESEHYDFILLDIMLPQLDGIEVCKRIRSKGNKTPIMMV
SAKGEEFDKVLALELGADDYMTKPFSPRELIARLKAILRRTEKTEEEDTTGLPEEYWTINHLVIYPERHEVYKNQKLLNL
TPKEFELLLYLVKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDDPKKPVFIKTIRGYGYKFKELKDETKS

Nucleotide

• Length: 723 bp

>NTDB_id=1140161 DQM95_RS03355 WP_012658092.1 588217..588939(+) (vicR) [Streptococcus uberis strain NCTC3858]
ATGAAAAAACATATTTTATTAGTCGATGATGAAGAACATATCTTACGTCTATTAGATTATCATTTGAAAAAAGAAGGTTA
TGAGACAGATCTTGCTGAGGATGGTAGGACAGCGCTAAAACTAGCAGAATCTGAACATTATGATTTTATTTTATTAGACA
TTATGTTGCCACAATTAGATGGTATTGAAGTCTGTAAAAGAATCCGTTCCAAGGGAAACAAGACTCCAATTATGATGGTA
TCTGCTAAAGGGGAGGAGTTTGATAAAGTACTAGCACTTGAACTTGGTGCTGATGATTATATGACAAAACCTTTTAGTCC
TAGAGAGTTAATTGCCAGATTAAAGGCTATTTTAAGACGAACTGAAAAAACTGAAGAAGAGGATACTACAGGTTTACCAG
AAGAATATTGGACTATTAATCACTTGGTTATTTATCCTGAAAGGCATGAAGTTTATAAAAATCAAAAGTTACTAAATCTA
ACACCGAAAGAATTTGAACTCTTACTTTATCTAGTCAAACATCCTAATATGACTCTAACAAGAGAACGACTCTTAGAACG
GATATGGGGTTATGATTTTGGACAAGAAACCCGTTTGGTAGATGTCCATATTGGTAAGTTGAGAGAAAAAATTGAGGATG
ATCCTAAAAAACCAGTGTTTATCAAAACGATTCGTGGATATGGTTATAAATTTAAGGAGCTAAAGGATGAAACAAAATCT
TAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-114)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (158-231)

3D structure

• AlphaFold DB: B9DRI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	52.137	97.5	0.508
micA	Streptococcus pneumoniae Cp1015	49.573	97.5	0.483
covR	Lactococcus lactis subsp. lactis strain DGCC12653	42.308	97.5	0.413
covR	Streptococcus salivarius strain HSISS4	40.343	97.083	0.392