Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM95_RS02440 Genome accession   NZ_LS483397
Coordinates   429022..429708 (+) Length   228 a.a.
NCBI ID   WP_012657914.1    Uniprot ID   B9DTP8
Organism   Streptococcus uberis strain NCTC3858     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 424022..434708
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM95_RS02415 (NCTC3858_00492) ktrB 424245..425636 (-) 1392 WP_269441091.1 potassium uptake transporter channel subunit KtrB -
  DQM95_RS02420 (NCTC3858_00493) rsmG 425708..426421 (-) 714 WP_012657909.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM95_RS02425 (NCTC3858_00494) - 426568..427125 (+) 558 WP_012657910.1 LemA family protein -
  DQM95_RS02430 (NCTC3858_00495) htpX 427160..428053 (+) 894 WP_012657911.1 zinc metalloprotease HtpX -
  DQM95_RS02435 (NCTC3858_00496) - 428266..428799 (+) 534 WP_012657912.1 DUF177 domain-containing protein -
  DQM95_RS02440 (NCTC3858_00497) covR 429022..429708 (+) 687 WP_012657914.1 two-component system response regulator CovR Regulator
  DQM95_RS02445 (NCTC3858_00498) - 429712..431214 (+) 1503 WP_037592457.1 ATP-binding protein -
  DQM95_RS02450 (NCTC3858_00499) nrdR 431377..431871 (+) 495 WP_012657916.1 transcriptional regulator NrdR -
  DQM95_RS02455 (NCTC3858_00500) - 431855..433051 (+) 1197 WP_037592455.1 DnaD domain protein -
  DQM95_RS02460 (NCTC3858_00501) dnaI 433052..433954 (+) 903 WP_012657918.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26623.61 Da        Isoelectric Point: 4.6541

>NTDB_id=1140153 DQM95_RS02440 WP_012657914.1 429022..429708(+) (covR) [Streptococcus uberis strain NCTC3858]
MTKKILIVEDEKNLARFVSLELQHEGYEVTVEVNGREGLETALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIETEKKAPNQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMSNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDMPGRESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1140153 DQM95_RS02440 WP_012657914.1 429022..429708(+) (covR) [Streptococcus uberis strain NCTC3858]
ATGACAAAGAAAATTTTAATCGTTGAAGATGAGAAAAATCTTGCGAGATTTGTATCTTTAGAATTACAACATGAAGGTTA
TGAAGTAACAGTCGAGGTAAATGGGCGTGAAGGTTTAGAAACGGCTCTTGAAAAAGACTTTGATTTAATCCTTTTAGATT
TAATGTTACCTGAAATGGATGGTTTTGAAGTGACACGTCGCTTACAGACTGAGAAAACAACCTATATCATGATGATGACT
GCACGTGATTCTATCATGGATGTCGTGGCAGGTTTAGACCGTGGTGCGGATGATTATATTGTTAAACCATTTGCCATTGA
AGAGTTATTAGCACGTATCAGAGCGATTTTCCGTCGTCAAGACATTGAAACAGAGAAGAAAGCTCCCAATCAAGGAATCT
ATCGTGATTTAGTTTTAAATCCACAAAATCGTTCAGTCAACCGTGGTGATGATGAAATTTCATTAACAAAACGTGAATAT
GATTTGTTAAATATTCTTATGTCAAATATGAACCGTGTTATGACACGTGAAGAATTATTATCAAACGTTTGGAAATATGA
CGAAGCAGTGGAAACAAATGTTGTTGATGTCTATATTCGTTACCTTCGTGGAAAAATTGACATGCCTGGAAGAGAGTCAT
ACATTCAAACAGTTCGTGGAATGGGATACGTAATTCGCGAGAAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B9DTP8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

83.406

100

0.838
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.723

100

0.443
  micA Streptococcus pneumoniae Cp1015

43.478

100

0.439

Multiple sequence alignment