Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQN61_RS01565 Genome accession   NZ_LS483391
Coordinates   283924..284610 (+) Length   228 a.a.
NCBI ID   WP_072135759.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8320     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 278924..289610
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN61_RS01540 (NCTC8320_00309) ktrB 279066..280442 (-) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -
  DQN61_RS01545 (NCTC8320_00310) rsmG 280527..281240 (-) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQN61_RS01550 (NCTC8320_00311) - 281390..281947 (+) 558 WP_002985956.1 LemA family protein -
  DQN61_RS01555 (NCTC8320_00312) htpX 281994..282890 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQN61_RS01560 (NCTC8320_00313) - 283124..283657 (+) 534 WP_011017345.1 YceD family protein -
  DQN61_RS01565 (NCTC8320_00314) covR 283924..284610 (+) 687 WP_072135759.1 two-component system response regulator CovR Regulator
  DQN61_RS01570 (NCTC8320_00315) covS 284616..286118 (+) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  DQN61_RS01575 (NCTC8320_00316) nrdR 286333..286827 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQN61_RS01580 (NCTC8320_00317) - 286811..287986 (+) 1176 WP_011017347.1 replication initiation and membrane attachment family protein -
  DQN61_RS01585 (NCTC8320_00318) dnaI 287987..288889 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26628.73 Da        Isoelectric Point: 4.6586

>NTDB_id=1139974 DQN61_RS01565 WP_072135759.1 283924..284610(+) (covR) [Streptococcus pyogenes strain NCTC8320]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEIPLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1139974 DQN61_RS01565 WP_072135759.1 283924..284610(+) (covR) [Streptococcus pyogenes strain NCTC8320]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTCCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.533

100

0.829
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment