Detailed information NTG1139947

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: DQM93_RS10725
• Genome accession: NZ_LS483390
• Coordinates: 2006664..2007326 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649974.1
• Uniprot ID: A0A0F7YBW3
• Organism: Streptococcus pneumoniae strain NCTC13276
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2001664..2012326

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM93_RS10700 (NCTC13276_02054)	-	2001814..2002080 (-)	267	WP_001278167.1	Veg family protein	-
DQM93_RS10705 (NCTC13276_02055)	dnaB	2002082..2003434 (-)	1353	WP_000852486.1	replicative DNA helicase	-
DQM93_RS10710 (NCTC13276_02056)	rplI	2003478..2003930 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
DQM93_RS10715 (NCTC13276_02057)	-	2003927..2005900 (-)	1974	WP_000715109.1	DHH family phosphoesterase	-
DQM93_RS10720 (NCTC13276_02058)	hpf	2006036..2006584 (-)	549	WP_000599104.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
DQM93_RS10725 (NCTC13276_02059)	comFC/cflB	2006664..2007326 (-)	663	WP_000649974.1	ComF family protein	Machinery gene
DQM93_RS10730 (NCTC13276_02060)	comFA/cflA	2007323..2008621 (-)	1299	WP_000867601.1	DEAD/DEAH box helicase	Machinery gene
DQM93_RS10735 (NCTC13276_02061)	-	2008677..2009312 (+)	636	WP_000395739.1	YigZ family protein	-
DQM93_RS10740 (NCTC13276_02062)	cysK	2009597..2010517 (+)	921	WP_000029860.1	cysteine synthase A	-
DQM93_RS10750 (NCTC13276_02063)	-	2010756..2011106 (-)	351	Protein_1991	IS66 family transposase	-
DQM93_RS10755	-	2011106..2011377 (+)	272	Protein_1992	transposase	-
DQM93_RS10760 (NCTC13276_02064)	tnpB	2011568..2011855 (-)	288	WP_000973412.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25169.03 Da
• Isoelectric Point: 7.7116

>NTDB_id=1139947 DQM93_RS10725 WP_000649974.1 2006664..2007326(-) (comFC/cflB) [Streptococcus pneumoniae strain NCTC13276]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQLWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=1139947 DQM93_RS10725 WP_000649974.1 2006664..2007326(-) (comFC/cflB) [Streptococcus pneumoniae strain NCTC13276]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAACTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTAGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCCGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A0F7YBW3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	100	100	1
comFC/cflB	Streptococcus pneumoniae D39	100	100	1
comFC/cflB	Streptococcus pneumoniae R6	100	100	1
comFC/cflB	Streptococcus pneumoniae TIGR4	99.545	100	0.995
comFC/cflB	Streptococcus mitis NCTC 12261	91.364	100	0.914
comFC/cflB	Streptococcus mitis SK321	90.909	100	0.909