Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM81_RS08330 Genome accession   NZ_LS483389
Coordinates   1603504..1604190 (-) Length   228 a.a.
NCBI ID   WP_111688345.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10879     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1598504..1609190
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM81_RS08310 (NCTC10879_01669) dnaI 1599225..1600127 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DQM81_RS08315 (NCTC10879_01670) - 1600128..1601303 (-) 1176 WP_032465854.1 replication initiation and membrane attachment family protein -
  DQM81_RS08320 (NCTC10879_01671) nrdR 1601287..1601781 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQM81_RS08325 (NCTC10879_01672) covS 1601996..1603498 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQM81_RS08330 (NCTC10879_01673) covR 1603504..1604190 (-) 687 WP_111688345.1 two-component system response regulator CovR Regulator
  DQM81_RS08335 (NCTC10879_01674) - 1604457..1604990 (-) 534 WP_011054200.1 YceD family protein -
  DQM81_RS08340 (NCTC10879_01675) htpX 1605224..1606120 (-) 897 WP_111688346.1 zinc metalloprotease HtpX -
  DQM81_RS08345 (NCTC10879_01676) - 1606167..1606724 (-) 558 WP_002985956.1 LemA family protein -
  DQM81_RS08350 (NCTC10879_01677) rsmG 1606874..1607587 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM81_RS08355 (NCTC10879_01678) ktrB 1607672..1609048 (+) 1377 WP_032459750.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26632.72 Da        Isoelectric Point: 4.6586

>NTDB_id=1139870 DQM81_RS08330 WP_111688345.1 1603504..1604190(-) (covR) [Streptococcus pyogenes strain NCTC10879]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRIMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1139870 DQM81_RS08330 WP_111688345.1 1603504..1604190(-) (covR) [Streptococcus pyogenes strain NCTC10879]
ATGACAAAGAAGATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTATCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.534

100

0.443
  micA Streptococcus pneumoniae Cp1015

41.739

100

0.421

Multiple sequence alignment