Detailed information NTG1139825

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM81_RS00265
• Genome accession: NZ_LS483389
• Coordinates: 46557..47468 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC10879
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 41557..52468

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM81_RS00245 (NCTC10879_00049)	purE	42143..42634 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM81_RS00250 (NCTC10879_00050)	purK	42621..43694 (+)	1074	WP_063629570.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM81_RS00255 (NCTC10879_00051)	-	43696..45114 (+)	1419	WP_111688213.1	hypothetical protein	-
DQM81_RS00260 (NCTC10879_00052)	purB	45134..46426 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
DQM81_RS00265 (NCTC10879_00053)	comR	46557..47468 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQM81_RS10205 (NCTC10879_00054)	comS	47552..47647 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM81_RS00270 (NCTC10879_00055)	ruvB	47694..48692 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQM81_RS00275 (NCTC10879_00056)	-	48830..49267 (+)	438	WP_038433843.1	low molecular weight protein-tyrosine-phosphatase	-
DQM81_RS00280 (NCTC10879_00057)	-	49290..49691 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQM81_RS00285 (NCTC10879_00058)	-	49688..51463 (+)	1776	WP_023612103.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1139825 DQM81_RS00265 WP_002986681.1 46557..47468(+) (comR) [Streptococcus pyogenes strain NCTC10879]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1139825 DQM81_RS00265 WP_002986681.1 46557..47468(+) (comR) [Streptococcus pyogenes strain NCTC10879]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462