Detailed information NTG1139058

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: DQM66_RS08495
• Genome accession: NZ_LS483374
• Coordinates: 1609621..1610280 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain NCTC7466
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1604621..1615280

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM66_RS08455 (NCTC7466_01623)	mgaSpn	1604778..1606259 (-)	1482	WP_001205275.1	virulence factor transcriptional regulator MgaSpn	-
DQM66_RS11840	-	1606643..1606865 (+)	223	Protein_1601	GlsB/YeaQ/YmgE family stress response membrane protein	-
DQM66_RS08465 (NCTC7466_01624)	amaP	1606949..1607515 (+)	567	WP_000030209.1	alkaline shock response membrane anchor protein AmaP	-
DQM66_RS08470 (NCTC7466_01625)	-	1607527..1607697 (+)	171	WP_000455066.1	DUF2273 domain-containing protein	-
DQM66_RS08475 (NCTC7466_01626)	-	1607736..1608344 (+)	609	WP_000064115.1	Asp23/Gls24 family envelope stress response protein	-
DQM66_RS08480 (NCTC7466_01627)	-	1608375..1608578 (+)	204	WP_000109957.1	CsbD family protein	-
DQM66_RS08485	-	1608688..1608927 (-)	240	WP_001005783.1	transposase	-
DQM66_RS08490 (NCTC7466_01628)	-	1609105..1609551 (-)	447	WP_000155429.1	GNAT family N-acetyltransferase	-
DQM66_RS08495 (NCTC7466_01629)	cclA/cilC	1609621..1610280 (+)	660	WP_000565010.1	prepilin peptidase	Machinery gene
DQM66_RS08500 (NCTC7466_01630)	-	1610332..1611483 (-)	1152	WP_000481753.1	helix-turn-helix domain-containing protein	-
DQM66_RS08505 (NCTC7466_01631)	-	1611498..1612229 (-)	732	WP_000934017.1	hypothetical protein	-
DQM66_RS08510	-	1612449..1612559 (+)	111	Protein_1611	prepilin peptidase	-
DQM66_RS08515 (NCTC7466_01632)	trpA	1612531..1613307 (-)	777	WP_001127036.1	tryptophan synthase subunit alpha	-
DQM66_RS08520 (NCTC7466_01633)	trpB	1613300..1614523 (-)	1224	WP_000331283.1	tryptophan synthase subunit beta	-
DQM66_RS08525 (NCTC7466_01634)	-	1614501..1615100 (-)	600	WP_000169895.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=1139058 DQM66_RS08495 WP_000565010.1 1609621..1610280(+) (cclA/cilC) [Streptococcus pneumoniae strain NCTC7466]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=1139058 DQM66_RS08495 WP_000565010.1 1609621..1610280(+) (cclA/cilC) [Streptococcus pneumoniae strain NCTC7466]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877