Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM51_RS01890 Genome accession   NZ_LS483356
Coordinates   333155..333841 (+) Length   228 a.a.
NCBI ID   WP_111713151.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8230     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 328155..338841
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM51_RS01865 (NCTC8230_00371) ktrB 328296..329672 (-) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -
  DQM51_RS01870 (NCTC8230_00372) rsmG 329757..330470 (-) 714 WP_111685178.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM51_RS01875 (NCTC8230_00373) - 330621..331178 (+) 558 WP_002985956.1 LemA family protein -
  DQM51_RS01880 (NCTC8230_00374) htpX 331225..332121 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQM51_RS01885 (NCTC8230_00375) - 332355..332888 (+) 534 WP_172452784.1 YceD family protein -
  DQM51_RS01890 (NCTC8230_00376) covR 333155..333841 (+) 687 WP_111713151.1 two-component system response regulator CovR Regulator
  DQM51_RS01895 (NCTC8230_00377) covS 333847..335349 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQM51_RS01900 (NCTC8230_00378) nrdR 335564..336058 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQM51_RS01905 (NCTC8230_00379) - 336042..337217 (+) 1176 WP_032467298.1 replication initiation and membrane attachment family protein -
  DQM51_RS01910 (NCTC8230_00380) dnaI 337218..338120 (+) 903 WP_002985938.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26592.66 Da        Isoelectric Point: 4.7279

>NTDB_id=1138265 DQM51_RS01890 WP_111713151.1 333155..333841(+) (covR) [Streptococcus pyogenes strain NCTC8230]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESHIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1138265 DQM51_RS01890 WP_111713151.1 333155..333841(+) (covR) [Streptococcus pyogenes strain NCTC8230]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTC
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.534

100

0.443
  micA Streptococcus pneumoniae Cp1015

41.739

100

0.421

Multiple sequence alignment