Detailed information NTG1138246

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM51_RS00335
• Genome accession: NZ_LS483356
• Coordinates: 54250..55161 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8230
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 49250..60161

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM51_RS00315 (NCTC8230_00064)	purE	49544..50035 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM51_RS00320 (NCTC8230_00065)	purK	50022..51095 (+)	1074	WP_172452778.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM51_RS00325 (NCTC8230_00066)	-	51116..52456 (+)	1341	WP_002987721.1	hypothetical protein	-
DQM51_RS00330 (NCTC8230_00067)	purB	52825..54117 (+)	1293	WP_111713105.1	adenylosuccinate lyase	-
DQM51_RS00335 (NCTC8230_00068)	comR	54250..55161 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQM51_RS10605 (NCTC8230_00069)	comS	55245..55340 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM51_RS00340 (NCTC8230_00070)	ruvB	55387..56385 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQM51_RS00345 (NCTC8230_00071)	-	56523..56960 (+)	438	WP_002986675.1	low molecular weight protein-tyrosine-phosphatase	-
DQM51_RS00350 (NCTC8230_00072)	-	56983..57384 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQM51_RS00355 (NCTC8230_00073)	-	57381..59156 (+)	1776	WP_002986669.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1138246 DQM51_RS00335 WP_002986681.1 54250..55161(+) (comR) [Streptococcus pyogenes strain NCTC8230]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1138246 DQM51_RS00335 WP_002986681.1 54250..55161(+) (comR) [Streptococcus pyogenes strain NCTC8230]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462