Detailed information NTG1138193

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL02_RS00330
• Genome accession: NZ_LS483355
• Coordinates: 52878..53789 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12067
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47878..58789

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL02_RS00310 (NCTC12067_00062)	purE	48465..48956 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL02_RS00315 (NCTC12067_00063)	purK	48943..50016 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL02_RS00320 (NCTC12067_00064)	-	50018..51436 (+)	1419	WP_023612101.1	hypothetical protein	-
DQL02_RS00325 (NCTC12067_00065)	purB	51456..52748 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
DQL02_RS00330 (NCTC12067_00066)	comR	52878..53789 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQL02_RS09190 (NCTC12067_00067)	comS	53873..53968 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQL02_RS00335 (NCTC12067_00068)	ruvB	54015..55013 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL02_RS00340 (NCTC12067_00069)	-	55151..55588 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
DQL02_RS00345 (NCTC12067_00070)	-	55612..56013 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQL02_RS00350 (NCTC12067_00071)	-	56010..57785 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1138193 DQL02_RS00330 WP_002986681.1 52878..53789(+) (comR) [Streptococcus pyogenes strain NCTC12067]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1138193 DQL02_RS00330 WP_002986681.1 52878..53789(+) (comR) [Streptococcus pyogenes strain NCTC12067]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462