Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL39_RS06720 Genome accession   NZ_LS483353
Coordinates   1303681..1304367 (-) Length   228 a.a.
NCBI ID   WP_111718089.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC4001     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1298681..1309367
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL39_RS06700 (NCTC4001_01337) dnaI 1299402..1300304 (-) 903 WP_038433694.1 primosomal protein DnaI -
  DQL39_RS06705 (NCTC4001_01338) - 1300305..1301480 (-) 1176 WP_030127140.1 replication initiation and membrane attachment family protein -
  DQL39_RS06710 (NCTC4001_01339) nrdR 1301464..1301958 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQL39_RS06715 (NCTC4001_01340) covS 1302173..1303675 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  DQL39_RS06720 (NCTC4001_01341) covR 1303681..1304367 (-) 687 WP_111718089.1 two-component system response regulator CovR Regulator
  DQL39_RS06725 (NCTC4001_01342) - 1304634..1305167 (-) 534 WP_011054200.1 YceD family protein -
  DQL39_RS06730 (NCTC4001_01343) htpX 1305401..1306297 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL39_RS06735 (NCTC4001_01344) - 1306344..1306901 (-) 558 WP_002985956.1 LemA family protein -
  DQL39_RS06740 (NCTC4001_01345) rsmG 1307051..1307764 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL39_RS06745 (NCTC4001_01346) ktrB 1307849..1309225 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26560.66 Da        Isoelectric Point: 4.7194

>NTDB_id=1138105 DQL39_RS06720 WP_111718089.1 1303681..1304367(-) (covR) [Streptococcus pyogenes strain NCTC4001]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGGDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1138105 DQL39_RS06720 WP_111718089.1 1303681..1304367(-) (covR) [Streptococcus pyogenes strain NCTC4001]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGGCGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(150-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

44.397

100

0.452
  micA Streptococcus pneumoniae Cp1015

42.609

100

0.43

Multiple sequence alignment