Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM42_RS01835 Genome accession   NZ_LS483351
Coordinates   322799..323485 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8195     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 317799..328485
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM42_RS01810 (NCTC8195_00364) ktrB 317941..319317 (-) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -
  DQM42_RS01815 (NCTC8195_00365) rsmG 319402..320115 (-) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM42_RS01820 (NCTC8195_00366) - 320265..320822 (+) 558 WP_002985956.1 LemA family protein -
  DQM42_RS01825 (NCTC8195_00367) htpX 320869..321765 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQM42_RS01830 (NCTC8195_00368) - 321999..322532 (+) 534 WP_011054200.1 YceD family protein -
  DQM42_RS01835 (NCTC8195_00369) covR 322799..323485 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQM42_RS01840 (NCTC8195_00370) covS 323491..324993 (+) 1503 WP_111690643.1 two-component system sensor histidine kinase CovS -
  DQM42_RS01845 (NCTC8195_00371) nrdR 325208..325702 (+) 495 WP_111690644.1 transcriptional regulator NrdR -
  DQM42_RS01850 (NCTC8195_00372) - 325686..326861 (+) 1176 WP_032467298.1 replication initiation and membrane attachment family protein -
  DQM42_RS01855 (NCTC8195_00373) dnaI 326862..327764 (+) 903 WP_002985938.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1137982 DQM42_RS01835 WP_002991052.1 322799..323485(+) (covR) [Streptococcus pyogenes strain NCTC8195]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1137982 DQM42_RS01835 WP_002991052.1 322799..323485(+) (covR) [Streptococcus pyogenes strain NCTC8195]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment