Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM50_RS08435 Genome accession   NZ_LS483347
Coordinates   1609573..1610259 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8324     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1604573..1615259
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM50_RS08415 (NCTC8324_01689) dnaI 1605294..1606196 (-) 903 WP_111688538.1 primosomal protein DnaI -
  DQM50_RS08420 (NCTC8324_01690) - 1606197..1607372 (-) 1176 WP_009880401.1 replication initiation and membrane attachment family protein -
  DQM50_RS08425 (NCTC8324_01691) nrdR 1607356..1607850 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQM50_RS08430 (NCTC8324_01692) covS 1608065..1609567 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQM50_RS08435 (NCTC8324_01693) covR 1609573..1610259 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQM50_RS08440 (NCTC8324_01694) - 1610526..1611059 (-) 534 WP_011054200.1 YceD family protein -
  DQM50_RS08445 (NCTC8324_01695) htpX 1611293..1612189 (-) 897 WP_085613923.1 zinc metalloprotease HtpX -
  DQM50_RS08450 (NCTC8324_01696) - 1612236..1612793 (-) 558 WP_002985956.1 LemA family protein -
  DQM50_RS08455 (NCTC8324_01697) rsmG 1612943..1613656 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM50_RS08460 (NCTC8324_01698) ktrB 1613741..1615117 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1137783 DQM50_RS08435 WP_002991052.1 1609573..1610259(-) (covR) [Streptococcus pyogenes strain NCTC8324]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1137783 DQM50_RS08435 WP_002991052.1 1609573..1610259(-) (covR) [Streptococcus pyogenes strain NCTC8324]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment