Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL69_RS07560 Genome accession   NZ_LS483345
Coordinates   1489364..1490050 (-) Length   228 a.a.
NCBI ID   WP_032461720.1    Uniprot ID   A0A5K8ALM6
Organism   Streptococcus pyogenes strain NCTC8231     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1484364..1495050
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL69_RS07540 (NCTC8231_01491) dnaI 1485085..1485987 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DQL69_RS07545 (NCTC8231_01492) - 1485988..1487163 (-) 1176 WP_032465854.1 replication initiation and membrane attachment family protein -
  DQL69_RS07550 (NCTC8231_01493) nrdR 1487147..1487641 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQL69_RS07555 (NCTC8231_01494) covS 1487856..1489358 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQL69_RS07560 (NCTC8231_01495) covR 1489364..1490050 (-) 687 WP_032461720.1 two-component system response regulator CovR Regulator
  DQL69_RS07565 (NCTC8231_01496) - 1490317..1490850 (-) 534 WP_011054200.1 YceD family protein -
  DQL69_RS07570 (NCTC8231_01497) htpX 1491084..1491980 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL69_RS07575 (NCTC8231_01498) - 1492027..1492584 (-) 558 WP_002985956.1 LemA family protein -
  DQL69_RS07580 (NCTC8231_01499) rsmG 1492734..1493447 (+) 714 WP_047235964.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL69_RS07585 (NCTC8231_01500) ktrB 1493532..1494908 (+) 1377 WP_033887684.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26565.65 Da        Isoelectric Point: 4.5945

>NTDB_id=1137664 DQL69_RS07560 WP_032461720.1 1489364..1490050(-) (covR) [Streptococcus pyogenes strain NCTC8231]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTCRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1137664 DQL69_RS07560 WP_032461720.1 1489364..1490050(-) (covR) [Streptococcus pyogenes strain NCTC8231]
ATGACAAAGAAGATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCTGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5K8ALM6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment