Detailed information NTG1137619

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: DQL21_RS09430
• Genome accession: NZ_LS483343
• Coordinates: 1846651..1847340 (-)
• Length: 229 a.a.
• NCBI ID: WP_018030434.1
• Uniprot ID: A0A2X3WBH1
• Organism: Streptococcus ferus strain NCTC12278
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	1848098..1853684	1846651..1847340	flank	758

Gene organization within MGE regions

Location: 1846651..1853684

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL21_RS09430 (NCTC12278_01895)	vicR	1846651..1847340 (-)	690	WP_018030434.1	response regulator transcription factor	Regulator
DQL21_RS09435 (NCTC12278_01896)	-	1847464..1848063 (+)	600	WP_018030433.1	histidine phosphatase family protein	-
DQL21_RS09440 (NCTC12278_01897)	-	1848098..1848715 (-)	618	WP_018030432.1	transglycosylase SLT domain-containing protein	-
DQL21_RS09445 (NCTC12278_01898)	-	1848889..1849680 (-)	792	WP_018030431.1	LysM domain-containing protein	-
DQL21_RS09450 (NCTC12278_01900)	-	1849858..1851203 (+)	1346	WP_169331543.1	IS3 family transposase	-
DQL21_RS09455 (NCTC12278_01901)	-	1851237..1852031 (-)	795	WP_018030428.1	energy-coupling factor transporter transmembrane protein EcfT	-
DQL21_RS09460 (NCTC12278_01902)	-	1852024..1852866 (-)	843	WP_018030427.1	energy-coupling factor ABC transporter ATP-binding protein	-
DQL21_RS09465 (NCTC12278_01903)	-	1852842..1853684 (-)	843	WP_018030426.1	energy-coupling factor ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 229 a.a.
• Molecular weight: 26665.88 Da
• Isoelectric Point: 5.1313

>NTDB_id=1137619 DQL21_RS09430 WP_018030434.1 1846651..1847340(-) (vicR) [Streptococcus ferus strain NCTC12278]
MKRVLLVDDERSILELLAFHFENEGYQVNLAEDGRTALDLALEKAYDFIVLDLMLPKLDGIEVCKRIRQANIETPIMMLT
AKGDEIDKILGLELGADDYMTKPFSPRELLARVKVILRRLEKADKQMEDEEVLSYDSLLIYVERNEVYKEHHPISLTKKE
FELLVYLAKRPGRTLSRERLLEMVWGFDYSDETRLVDVHIGKLREKIEDDTKHPSFIKTVRGFGYKFGG

Nucleotide

• Length: 690 bp

>NTDB_id=1137619 DQL21_RS09430 WP_018030434.1 1846651..1847340(-) (vicR) [Streptococcus ferus strain NCTC12278]
ATGAAAAGGGTATTGCTTGTCGATGATGAACGGAGTATTCTTGAATTGCTGGCCTTTCATTTTGAAAATGAGGGCTATCA
GGTAAACTTGGCAGAAGATGGTCGTACGGCCTTAGACTTGGCTTTGGAGAAAGCCTATGATTTTATTGTTTTGGATCTTA
TGCTCCCTAAACTAGATGGAATTGAAGTCTGCAAGCGTATCCGCCAAGCCAACATAGAGACTCCCATCATGATGCTGACC
GCTAAGGGTGACGAAATCGATAAAATATTGGGTCTGGAACTGGGAGCCGATGATTATATGACCAAGCCCTTCAGCCCAAG
AGAGCTTTTGGCAAGGGTCAAGGTTATTTTGCGACGTCTGGAAAAGGCTGATAAGCAGATGGAAGATGAAGAAGTGCTGT
CTTACGACTCCTTGTTGATCTACGTTGAGCGGAATGAAGTGTACAAGGAACATCACCCCATTTCGCTGACAAAGAAAGAA
TTTGAGCTGTTAGTTTATCTGGCGAAGAGACCTGGACGGACCCTCAGCCGCGAAAGGCTTTTAGAGATGGTTTGGGGCTT
TGATTATTCAGATGAAACACGCCTGGTGGACGTTCATATCGGAAAACTCCGTGAAAAAATTGAGGATGATACGAAGCATC
CTAGCTTTATCAAAACAGTCAGAGGTTTTGGCTATAAATTTGGAGGCTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (152-227)

• Response regulator receiver domain (Response_reg) (4-114)

3D structure

• AlphaFold DB: A0A2X3WBH1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	47.436	100	0.485
micA	Streptococcus pneumoniae Cp1015	48.035	100	0.48
covR	Lactococcus lactis subsp. lactis strain DGCC12653	42.411	97.817	0.415
covR	Streptococcus salivarius strain HSISS4	42.411	97.817	0.415