Detailed information NTG1137366

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQL34_RS06485
• Genome accession: NZ_LS483339
• Coordinates: 1204814..1206154 (-)
• Length: 446 a.a.
• NCBI ID: WP_084828862.1
• Uniprot ID: A0A0E2Q0P2
• Organism: Streptococcus thermophilus strain NCTC12958
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1199814..1211154

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL34_RS06455 (NCTC12958_01344)	-	1199924..1200310 (-)	387	WP_084828860.1	DUF1934 domain-containing protein	-
DQL34_RS06460	-	1200368..1201282 (-)	915	Protein_1211	GNAT family N-acetyltransferase	-
DQL34_RS06465 (NCTC12958_01346)	yidA	1201490..1202299 (+)	810	WP_011226081.1	sugar-phosphatase	-
DQL34_RS06470 (NCTC12958_01347)	-	1202301..1203515 (+)	1215	WP_084830670.1	aminoacyltransferase	-
DQL34_RS06475 (NCTC12958_01348)	-	1203567..1203919 (-)	353	Protein_1214	YbaN family protein	-
DQL34_RS06480 (NCTC12958_01349)	vicX	1203996..1204805 (-)	810	WP_100262465.1	MBL fold metallo-hydrolase	Regulator
DQL34_RS06485 (NCTC12958_01350)	vicK	1204814..1206154 (-)	1341	WP_084828862.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQL34_RS06490 (NCTC12958_01351)	vicR	1206147..1206854 (-)	708	WP_011681206.1	response regulator YycF	Regulator
DQL34_RS06495 (NCTC12958_01352)	-	1207381..1208148 (+)	768	WP_011681207.1	amino acid ABC transporter ATP-binding protein	-
DQL34_RS06500 (NCTC12958_01353)	-	1208160..1208993 (+)	834	WP_002953142.1	transporter substrate-binding domain-containing protein	-
DQL34_RS06505 (NCTC12958_01354)	-	1209011..1209709 (+)	699	WP_014608374.1	amino acid ABC transporter permease	-
DQL34_RS06510 (NCTC12958_01355)	-	1209721..1210371 (+)	651	WP_100273221.1	amino acid ABC transporter permease	-

Sequence

Protein

• Length: 446 a.a.
• Molecular weight: 50777.01 Da
• Isoelectric Point: 5.2465

>NTDB_id=1137366 DQL34_RS06485 WP_084828862.1 1204814..1206154(-) (vicK) [Streptococcus thermophilus strain NCTC12958]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYQQVKNIRKLTKRVKSLMAGNYNEKLRIKGDSELLELANSLNDLSDV
FRLTHENLIQEKNRLSSVLSYMSDGVIATNRLGQITMINSTAQRLLNLDRETATQMSILDILDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALNE
EIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLNVEMTNFTAFMTYILNRFGQIKSQETNPGKSYEIIRDYPVNSI
WVEIDTDKMTQVVDNILNNAIKYSPDGGQITVSMKTTDTQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIVKQHNGFIWAKSEYGKGSTFTIVLPYDQDAMMVDEWEM

Nucleotide

• Length: 1341 bp

>NTDB_id=1137366 DQL34_RS06485 WP_084828862.1 1204814..1206154(-) (vicK) [Streptococcus thermophilus strain NCTC12958]
ATGACTAGTATTGGCTTAAATATTACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTCTTTGTTGCTTTCTATTTCAT
TTTTCTAGCTTATCGTGATTATCAACAGGTCAAAAATATCCGAAAGTTGACTAAGAGAGTCAAATCCCTTATGGCAGGTA
ATTATAATGAAAAATTACGCATAAAGGGAGATTCAGAGCTTTTAGAGCTAGCTAATAGCTTGAATGATTTGTCGGACGTC
TTTCGTTTGACACATGAAAATCTAATCCAGGAAAAAAACCGCTTATCATCTGTCCTTTCGTACATGAGTGACGGGGTTAT
TGCGACCAATCGCCTTGGTCAGATTACTATGATTAATAGTACTGCCCAACGCTTGTTGAATTTAGATCGCGAAACTGCGA
CTCAGATGTCTATTTTGGATATATTAGATGGTGAGAATCCCTATACCTATAGTGAATTGTTGTCTAAGACACCCGAAATC
CATCTGTCGCGTCGAGATGCTAACGATGAATTTGTGACGCTACGTGTTAATTTTGCATTAATTCGTAAGGAATCTGGTTT
TATTTCAGGTCTGGTAGCCGTTCTTCATGATGCCACTGAGCAGGAAAAAGAAGAGCGCGAACGCCGTCTCTTCGTATCAA
ATGTTAGTCACGAATTGCGGACGCCTTTAACTTCTGTGAAATCCTATCTTGAAGCGCTTGATGATGGTGCTCTCAACGAA
GAGATTGCTCCAAACTTTATCAAAGTTTCTTTAGATGAAACCAACCGCATGATGCGTATGATTTCTGACCTCTTGGCATT
ATCTCGAATTGACAATAAAAGCACACAGCTTAATGTTGAAATGACAAACTTTACAGCCTTTATGACCTATATCTTGAATC
GATTTGGTCAAATTAAGAGTCAAGAAACTAATCCAGGTAAGTCTTATGAAATCATTCGAGATTACCCAGTAAACTCTATT
TGGGTGGAAATTGATACTGATAAGATGACCCAGGTCGTAGATAATATACTTAATAATGCCATCAAGTATTCTCCTGATGG
TGGGCAAATTACAGTATCTATGAAAACGACAGACACTCAGTTGATTGTTTCTATTTCTGACCAAGGTTTAGGAATTCCTA
AAAAAGATTTACCTCTGATTTTTGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCTCAGGGTGGAACAGGACTT
GGCTTGTCCATAGCAAAAGAAATTGTTAAACAACATAATGGCTTCATTTGGGCTAAGAGTGAGTATGGTAAGGGGTCAAC
TTTTACAATTGTGCTTCCATATGACCAGGACGCAATGATGGTCGATGAATGGGAGATGTAG

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (325-435)

• PAS fold (PAS) (94-197)

• His Kinase A (phospho-acceptor) domain (HisKA) (208-272)

• HAMP domain (HAMP) (37-79)

3D structure

• AlphaFold DB: A0A0E2Q0P2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	73.913	92.825	0.686
micB	Streptococcus pneumoniae Cp1015	66.051	97.085	0.641