Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM35_RS07535 Genome accession   NZ_LS483338
Coordinates   1462151..1462837 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12064     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1457151..1467837
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM35_RS07515 (NCTC12064_01485) dnaI 1457872..1458774 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DQM35_RS07520 (NCTC12064_01486) - 1458775..1459950 (-) 1176 WP_009880401.1 replication initiation and membrane attachment family protein -
  DQM35_RS07525 (NCTC12064_01487) nrdR 1459934..1460428 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQM35_RS07530 (NCTC12064_01488) covS 1460643..1462145 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQM35_RS07535 (NCTC12064_01489) covR 1462151..1462837 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQM35_RS07540 (NCTC12064_01490) - 1463104..1463637 (-) 534 WP_014635288.1 DUF177 domain-containing protein -
  DQM35_RS07545 (NCTC12064_01491) htpX 1463871..1464767 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQM35_RS07550 (NCTC12064_01492) - 1464814..1465371 (-) 558 WP_038431211.1 LemA family protein -
  DQM35_RS07555 (NCTC12064_01493) rsmG 1465521..1466234 (+) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM35_RS07560 (NCTC12064_01494) ktrB 1466318..1467694 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1137322 DQM35_RS07535 WP_002991052.1 1462151..1462837(-) (covR) [Streptococcus pyogenes strain NCTC12064]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1137322 DQM35_RS07535 WP_002991052.1 1462151..1462837(-) (covR) [Streptococcus pyogenes strain NCTC12064]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment