Detailed information NTG1137166

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL08_RS00335
• Genome accession: NZ_LS483336
• Coordinates: 53140..54051 (+)
• Length: 303 a.a.
• NCBI ID: WP_023611326.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12046
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48140..59051

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL08_RS00315 (NCTC12046_00062)	purE	48436..48927 (+)	492	WP_023611331.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL08_RS00320 (NCTC12046_00063)	purK	48914..49987 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL08_RS00325 (NCTC12046_00064)	-	50008..51348 (+)	1341	WP_023611329.1	hypothetical protein	-
DQL08_RS00330 (NCTC12046_00065)	purB	51717..53009 (+)	1293	WP_023611333.1	adenylosuccinate lyase	-
DQL08_RS00335 (NCTC12046_00066)	comR	53140..54051 (+)	912	WP_023611326.1	transcriptional regulator Rgg4/ComR	Regulator
DQL08_RS09980 (NCTC12046_00067)	comS	54135..54230 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQL08_RS00340 (NCTC12046_00068)	ruvB	54277..55275 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL08_RS00345 (NCTC12046_00069)	-	55413..55850 (+)	438	WP_063662030.1	low molecular weight protein-tyrosine-phosphatase	-
DQL08_RS00350 (NCTC12046_00070)	-	55873..56274 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQL08_RS00355 (NCTC12046_00071)	-	56271..58046 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35685.21 Da
• Isoelectric Point: 4.5164

>NTDB_id=1137166 DQL08_RS00335 WP_023611326.1 53140..54051(+) (comR) [Streptococcus pyogenes strain NCTC12046]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSGQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1137166 DQL08_RS00335 WP_023611326.1 53140..54051(+) (comR) [Streptococcus pyogenes strain NCTC12046]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGGACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462