Detailed information NTG1136999

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL30_RS00330
• Genome accession: NZ_LS483333
• Coordinates: 52879..53790 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12048
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47879..58790

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL30_RS00310 (NCTC12048_00062)	purE	48465..48956 (+)	492	WP_041174354.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL30_RS00315 (NCTC12048_00063)	purK	48943..50016 (+)	1074	WP_014407196.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL30_RS00320 (NCTC12048_00064)	-	50018..51436 (+)	1419	WP_011888524.1	hypothetical protein	-
DQL30_RS00325 (NCTC12048_00065)	purB	51456..52748 (+)	1293	WP_014407197.1	adenylosuccinate lyase	-
DQL30_RS00330 (NCTC12048_00066)	comR	52879..53790 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQL30_RS09485	comS	53874..53969 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQL30_RS00335 (NCTC12048_00067)	ruvB	54016..55014 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL30_RS00340 (NCTC12048_00068)	-	55152..55589 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQL30_RS00345 (NCTC12048_00069)	-	55612..56013 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
DQL30_RS00350 (NCTC12048_00070)	-	56010..57785 (+)	1776	WP_053308140.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1136999 DQL30_RS00330 WP_002986681.1 52879..53790(+) (comR) [Streptococcus pyogenes strain NCTC12048]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1136999 DQL30_RS00330 WP_002986681.1 52879..53790(+) (comR) [Streptococcus pyogenes strain NCTC12048]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATTATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462