Detailed information NTG1136883

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL10_RS00335
• Genome accession: NZ_LS483331
• Coordinates: 52873..53784 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12057
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47873..58784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL10_RS00315 (NCTC12057_00062)	purE	48459..48950 (+)	492	WP_023612097.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL10_RS00320 (NCTC12057_00063)	purK	48937..50010 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL10_RS00325 (NCTC12057_00064)	-	50012..51430 (+)	1419	WP_023612101.1	hypothetical protein	-
DQL10_RS00330 (NCTC12057_00065)	purB	51450..52742 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
DQL10_RS00335 (NCTC12057_00066)	comR	52873..53784 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQL10_RS09645	comS	53864..53962 (+)	99	WP_206733287.1	quorum-sensing system DWW-type pheromone	Regulator
DQL10_RS00340 (NCTC12057_00067)	ruvB	54009..55007 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL10_RS00345 (NCTC12057_00068)	-	55145..55582 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQL10_RS00350 (NCTC12057_00069)	-	55605..56006 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQL10_RS00355 (NCTC12057_00070)	-	56003..57778 (+)	1776	WP_023612103.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1136883 DQL10_RS00335 WP_002986681.1 52873..53784(+) (comR) [Streptococcus pyogenes strain NCTC12057]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1136883 DQL10_RS00335 WP_002986681.1 52873..53784(+) (comR) [Streptococcus pyogenes strain NCTC12057]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462