Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL25_RS08025 Genome accession   NZ_LS483330
Coordinates   1558824..1559510 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8328     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1553824..1564510
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL25_RS08000 (NCTC8328_01598) - 1554123..1555298 (-) 1176 WP_030127140.1 replication initiation and membrane attachment family protein -
  DQL25_RS08005 (NCTC8328_01599) nrdR 1555282..1555776 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQL25_RS08015 (NCTC8328_01601) - 1555950..1557083 (-) 1134 WP_000564846.1 ISAs1-like element IS1548 family transposase -
  DQL25_RS08020 (NCTC8328_01602) covS 1557316..1558818 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQL25_RS08025 (NCTC8328_01603) covR 1558824..1559510 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQL25_RS08030 (NCTC8328_01604) - 1559777..1560310 (-) 534 WP_168391445.1 YceD family protein -
  DQL25_RS08035 (NCTC8328_01605) htpX 1560544..1561440 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL25_RS08040 (NCTC8328_01606) - 1561487..1562044 (-) 558 WP_111703535.1 LemA family protein -
  DQL25_RS08045 (NCTC8328_01607) rsmG 1562194..1562907 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL25_RS08050 (NCTC8328_01608) ktrB 1562992..1564368 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1136874 DQL25_RS08025 WP_002991052.1 1558824..1559510(-) (covR) [Streptococcus pyogenes strain NCTC8328]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1136874 DQL25_RS08025 WP_002991052.1 1558824..1559510(-) (covR) [Streptococcus pyogenes strain NCTC8328]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment