Detailed information NTG1136776

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL27_RS00330
• Genome accession: NZ_LS483329
• Coordinates: 52860..53771 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12058
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47860..58771

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL27_RS00310 (NCTC12058_00063)	purE	48446..48937 (+)	492	WP_023079557.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL27_RS00315 (NCTC12058_00064)	purK	48924..49997 (+)	1074	WP_172450281.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL27_RS00320 (NCTC12058_00065)	-	49999..51417 (+)	1419	WP_111711317.1	hypothetical protein	-
DQL27_RS00325 (NCTC12058_00066)	purB	51437..52729 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
DQL27_RS00330 (NCTC12058_00067)	comR	52860..53771 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQL27_RS09305 (NCTC12058_00068)	comS	53855..53950 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQL27_RS00335 (NCTC12058_00069)	ruvB	53997..54995 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL27_RS00340 (NCTC12058_00070)	-	55133..55570 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQL27_RS00345 (NCTC12058_00071)	-	55593..55994 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
DQL27_RS00350 (NCTC12058_00072)	-	55991..57766 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1136776 DQL27_RS00330 WP_002986681.1 52860..53771(+) (comR) [Streptococcus pyogenes strain NCTC12058]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1136776 DQL27_RS00330 WP_002986681.1 52860..53771(+) (comR) [Streptococcus pyogenes strain NCTC12058]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462