Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL59_RS00685 Genome accession   NZ_LS483326
Coordinates   109265..109951 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12045     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 104265..114951
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL59_RS00660 (NCTC12045_00133) ktrB 104407..105783 (-) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -
  DQL59_RS00665 (NCTC12045_00134) rsmG 105868..106581 (-) 714 WP_063629344.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL59_RS00670 (NCTC12045_00135) - 106731..107288 (+) 558 WP_111680971.1 LemA family protein -
  DQL59_RS00675 (NCTC12045_00136) htpX 107335..108231 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL59_RS00680 (NCTC12045_00137) - 108465..108998 (+) 534 WP_014635288.1 YceD family protein -
  DQL59_RS00685 (NCTC12045_00138) covR 109265..109951 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQL59_RS00690 (NCTC12045_00139) covS 109957..111459 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQL59_RS00695 (NCTC12045_00141) - 111693..112761 (+) 1069 Protein_98 ISAs1 family transposase -
  DQL59_RS00705 (NCTC12045_00143) nrdR 112935..113429 (+) 495 WP_031488561.1 transcriptional regulator NrdR -
  DQL59_RS00710 (NCTC12045_00144) - 113413..114588 (+) 1176 WP_031488562.1 replication initiation and membrane attachment family protein -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1136608 DQL59_RS00685 WP_002991052.1 109265..109951(+) (covR) [Streptococcus pyogenes strain NCTC12045]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1136608 DQL59_RS00685 WP_002991052.1 109265..109951(+) (covR) [Streptococcus pyogenes strain NCTC12045]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment