Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL15_RS07690 Genome accession   NZ_LS483323
Coordinates   1507262..1507948 (-) Length   228 a.a.
NCBI ID   WP_111689262.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8300     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1502262..1512948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL15_RS07670 (NCTC8300_01518) dnaI 1502983..1503885 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DQL15_RS07675 (NCTC8300_01519) - 1503886..1505061 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  DQL15_RS07680 (NCTC8300_01520) nrdR 1505045..1505539 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQL15_RS07685 (NCTC8300_01521) covS 1505754..1507256 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DQL15_RS07690 (NCTC8300_01522) covR 1507262..1507948 (-) 687 WP_111689262.1 two-component system response regulator CovR Regulator
  DQL15_RS07695 (NCTC8300_01523) - 1508215..1508748 (-) 534 WP_011054200.1 YceD family protein -
  DQL15_RS07700 (NCTC8300_01524) htpX 1508982..1509878 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL15_RS07705 (NCTC8300_01525) - 1509925..1510482 (-) 558 WP_002985956.1 LemA family protein -
  DQL15_RS07710 (NCTC8300_01526) rsmG 1510632..1511345 (+) 714 WP_002991057.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL15_RS07715 (NCTC8300_01527) ktrB 1511430..1512806 (+) 1377 WP_032459750.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26546.59 Da        Isoelectric Point: 4.6485

>NTDB_id=1136493 DQL15_RS07690 WP_111689262.1 1507262..1507948(-) (covR) [Streptococcus pyogenes strain NCTC8300]
MTNKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMGVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1136493 DQL15_RS07690 WP_111689262.1 1507262..1507948(-) (covR) [Streptococcus pyogenes strain NCTC8300]
ATGACAAATAAGATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGGTGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCTGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.223

100

0.816
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.079

99.561

0.658
  vicR Streptococcus mutans UA159

43.103

100

0.439
  micA Streptococcus pneumoniae Cp1015

41.304

100

0.417

Multiple sequence alignment