Detailed information NTG1136450

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL15_RS00340
• Genome accession: NZ_LS483323
• Coordinates: 53814..54725 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8300
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48814..59725

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL15_RS00320 (NCTC8300_00064)	-	49711..50805 (+)	1095	WP_231870735.1	hypothetical protein	-
DQL15_RS00325 (NCTC8300_00065)	-	50860..51723 (+)	864	WP_002987985.1	IS982-like element ISSpy2 family transposase	-
DQL15_RS00330 (NCTC8300_00066)	-	51739..52020 (+)	282	WP_231870736.1	hypothetical protein	-
DQL15_RS00335 (NCTC8300_00067)	purB	52389..53681 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
DQL15_RS00340 (NCTC8300_00068)	comR	53814..54725 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQL15_RS09395 (NCTC8300_00069)	comS	54809..54904 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQL15_RS00345 (NCTC8300_00070)	ruvB	54951..55949 (+)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
DQL15_RS00350 (NCTC8300_00071)	-	56087..56524 (+)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
DQL15_RS00355 (NCTC8300_00072)	-	56548..56949 (+)	402	WP_002987730.1	MORN repeat-containing protein	-
DQL15_RS00360 (NCTC8300_00073)	-	56946..58721 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1136450 DQL15_RS00340 WP_002986681.1 53814..54725(+) (comR) [Streptococcus pyogenes strain NCTC8300]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1136450 DQL15_RS00340 WP_002986681.1 53814..54725(+) (comR) [Streptococcus pyogenes strain NCTC8300]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462