Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL05_RS07355 Genome accession   NZ_LS483322
Coordinates   1441908..1442594 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12066     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1436908..1447594
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL05_RS07335 (NCTC12066_01455) dnaI 1437629..1438531 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DQL05_RS07340 (NCTC12066_01456) - 1438532..1439707 (-) 1176 WP_011017347.1 replication initiation and membrane attachment family protein -
  DQL05_RS07345 (NCTC12066_01457) nrdR 1439691..1440185 (-) 495 WP_011184190.1 transcriptional regulator NrdR -
  DQL05_RS07350 (NCTC12066_01458) covS 1440400..1441902 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  DQL05_RS07355 (NCTC12066_01459) covR 1441908..1442594 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQL05_RS07360 (NCTC12066_01460) - 1442861..1443394 (-) 534 WP_014635288.1 YceD family protein -
  DQL05_RS07365 (NCTC12066_01461) htpX 1443628..1444524 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL05_RS07370 (NCTC12066_01462) - 1444571..1445128 (-) 558 WP_002985956.1 LemA family protein -
  DQL05_RS07375 (NCTC12066_01463) rsmG 1445278..1445991 (+) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL05_RS07380 (NCTC12066_01464) ktrB 1446075..1447451 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1136440 DQL05_RS07355 WP_002991052.1 1441908..1442594(-) (covR) [Streptococcus pyogenes strain NCTC12066]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1136440 DQL05_RS07355 WP_002991052.1 1441908..1442594(-) (covR) [Streptococcus pyogenes strain NCTC12066]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
CGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAACGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment