Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQL09_RS01590 Genome accession   NZ_LS483307
Coordinates   289967..290653 (+) Length   228 a.a.
NCBI ID   WP_111677052.1    Uniprot ID   A0A5K8APQ0
Organism   Streptococcus pyogenes strain NCTC5163     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 284967..295653
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL09_RS01565 (NCTC5163_00304) ktrB 285109..286485 (-) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -
  DQL09_RS01570 (NCTC5163_00305) rsmG 286570..287283 (-) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQL09_RS01575 (NCTC5163_00306) - 287433..287990 (+) 558 WP_002985956.1 LemA family protein -
  DQL09_RS01580 (NCTC5163_00307) htpX 288037..288933 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQL09_RS01585 (NCTC5163_00308) - 289167..289700 (+) 534 WP_011054200.1 YceD family protein -
  DQL09_RS01590 (NCTC5163_00309) covR 289967..290653 (+) 687 WP_111677052.1 two-component system response regulator CovR Regulator
  DQL09_RS01595 (NCTC5163_00310) covS 290659..292161 (+) 1503 WP_111677053.1 two-component system sensor histidine kinase CovS -
  DQL09_RS01600 (NCTC5163_00311) nrdR 292376..292870 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQL09_RS01605 (NCTC5163_00312) - 292854..294029 (+) 1176 WP_030127140.1 replication initiation and membrane attachment family protein -
  DQL09_RS01610 (NCTC5163_00313) dnaI 294030..294932 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26599.65 Da        Isoelectric Point: 4.6576

>NTDB_id=1135765 DQL09_RS01590 WP_111677052.1 289967..290653(+) (covR) [Streptococcus pyogenes strain NCTC5163]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTHRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1135765 DQL09_RS01590 WP_111677052.1 289967..290653(+) (covR) [Streptococcus pyogenes strain NCTC5163]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCATCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAACCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5K8APQ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment