Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DQM39_RS08440 Genome accession   NZ_LS483298
Coordinates   1607238..1607924 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8225     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1602238..1612924
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM39_RS08420 (NCTC8225_01691) dnaI 1602959..1603861 (-) 903 WP_002985938.1 primosomal protein DnaI -
  DQM39_RS08425 (NCTC8225_01692) - 1603862..1605037 (-) 1176 WP_032467298.1 replication initiation and membrane attachment family protein -
  DQM39_RS08430 (NCTC8225_01693) nrdR 1605021..1605515 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DQM39_RS08435 (NCTC8225_01694) covS 1605787..1607232 (-) 1446 WP_111680894.1 two-component system sensor histidine kinase CovS -
  DQM39_RS08440 (NCTC8225_01695) covR 1607238..1607924 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DQM39_RS08445 (NCTC8225_01696) - 1608191..1608724 (-) 534 WP_011054200.1 YceD family protein -
  DQM39_RS08450 (NCTC8225_01697) htpX 1608958..1609854 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DQM39_RS08455 (NCTC8225_01698) - 1609901..1610458 (-) 558 WP_002985956.1 LemA family protein -
  DQM39_RS08460 (NCTC8225_01699) rsmG 1610608..1611321 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DQM39_RS08465 (NCTC8225_01700) ktrB 1611406..1612782 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1135487 DQM39_RS08440 WP_002991052.1 1607238..1607924(-) (covR) [Streptococcus pyogenes strain NCTC8225]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1135487 DQM39_RS08440 WP_002991052.1 1607238..1607924(-) (covR) [Streptococcus pyogenes strain NCTC8225]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment