Detailed information NTG1135441

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM39_RS00330
• Genome accession: NZ_LS483298
• Coordinates: 53168..54079 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8225
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48168..59079

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM39_RS00310 (NCTC8225_00063)	purE	48461..48952 (+)	492	WP_002986689.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM39_RS00315 (NCTC8225_00064)	purK	48939..50012 (+)	1074	WP_002986688.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM39_RS00320 (NCTC8225_00065)	-	50033..51373 (+)	1341	WP_002986685.1	hypothetical protein	-
DQM39_RS00325 (NCTC8225_00066)	purB	51742..53034 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
DQM39_RS00330 (NCTC8225_00067)	comR	53168..54079 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQM39_RS10340 (NCTC8225_00068)	comS	54163..54258 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM39_RS00335 (NCTC8225_00069)	ruvB	54305..55303 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQM39_RS00340 (NCTC8225_00070)	-	55441..55878 (+)	438	WP_002986675.1	low molecular weight protein-tyrosine-phosphatase	-
DQM39_RS00345 (NCTC8225_00071)	-	55901..56302 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQM39_RS00350 (NCTC8225_00072)	-	56299..58074 (+)	1776	WP_002986669.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1135441 DQM39_RS00330 WP_002986681.1 53168..54079(+) (comR) [Streptococcus pyogenes strain NCTC8225]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1135441 DQM39_RS00330 WP_002986681.1 53168..54079(+) (comR) [Streptococcus pyogenes strain NCTC8225]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462