Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H1W89_RS01725 Genome accession   NZ_LR822029
Coordinates   316108..316797 (+) Length   229 a.a.
NCBI ID   WP_014607969.1    Uniprot ID   A0A2H4K9N5
Organism   Streptococcus thermophilus isolate STH_CIRM_1035     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 311108..321797
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W89_RS09700 - 312074..312244 (+) 171 Protein_283 ascorbate 6-phosphate lactonase -
  H1W89_RS01705 (STHERMO_0334) - 312261..312932 (-) 672 WP_002946492.1 potassium channel family protein -
  H1W89_RS01710 (STHERMO_0335) - 312972..314336 (-) 1365 WP_014607967.1 TrkH family potassium uptake protein -
  H1W89_RS01715 (STHERMO_0336) rsmG 314406..315119 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H1W89_RS01720 (STHERMO_0337) - 315416..315952 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  H1W89_RS01725 (STHERMO_0338) covR 316108..316797 (+) 690 WP_014607969.1 response regulator transcription factor Regulator
  H1W89_RS01730 (STHERMO_0339) covS 316794..318311 (+) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  H1W89_RS01735 (STHERMO_0340) nrdR 318433..318912 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  H1W89_RS01740 (STHERMO_0341) - 318909..320084 (+) 1176 WP_180474498.1 DnaD domain protein -
  H1W89_RS01745 (STHERMO_0342) dnaI 320088..320990 (+) 903 WP_002946786.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26637.73 Da        Isoelectric Point: 4.7059

>NTDB_id=1131389 H1W89_RS01725 WP_014607969.1 316108..316797(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_1035]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLELALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1131389 H1W89_RS01725 WP_014607969.1 316108..316797(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_1035]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAATTGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAGACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9N5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

95.633

100

0.956
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment