Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H0508_RS01615 Genome accession   NZ_LR822014
Coordinates   302110..302799 (+) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus isolate STH_CIRM_36     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 297110..307799
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0508_RS09390 - 298076..298246 (+) 171 Protein_270 ascorbate 6-phosphate lactonase -
  H0508_RS01595 (STHERMO_0331) - 298263..298934 (-) 672 WP_179971566.1 potassium channel family protein -
  H0508_RS01600 (STHERMO_0332) - 298974..300338 (-) 1365 WP_269472543.1 TrkH family potassium uptake protein -
  H0508_RS01605 (STHERMO_0333) rsmG 300408..301121 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H0508_RS01610 (STHERMO_0334) - 301418..301954 (+) 537 WP_041826965.1 DUF177 domain-containing protein -
  H0508_RS01615 (STHERMO_0335) covR 302110..302799 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  H0508_RS01620 (STHERMO_0336) covS 302796..304313 (+) 1518 WP_002949640.1 HAMP domain-containing histidine kinase Regulator
  H0508_RS01625 (STHERMO_0337) nrdR 304435..304914 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  H0508_RS01630 (STHERMO_0338) - 304911..306086 (+) 1176 WP_011225482.1 DnaD domain protein -
  H0508_RS01635 (STHERMO_0339) dnaI 306090..306992 (+) 903 WP_002946786.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=1130835 H0508_RS01615 WP_002949638.1 302110..302799(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_36]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1130835 H0508_RS01615 WP_002949638.1 302110..302799(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_36]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTAGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment