Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   GPW69_RS04305 Genome accession   NZ_LR738724
Coordinates   861131..862510 (+) Length   459 a.a.
NCBI ID   WP_024413750.1    Uniprot ID   -
Organism   Streptococcus suis isolate 9401240     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 856131..867510
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GPW69_RS04275 pstA 856400..857287 (+) 888 WP_074391085.1 phosphate ABC transporter permease PstA -
  GPW69_RS04280 pstB 857312..858115 (+) 804 WP_002940866.1 phosphate ABC transporter ATP-binding protein PstB -
  GPW69_RS04285 pstB 858127..858885 (+) 759 WP_074391084.1 phosphate ABC transporter ATP-binding protein PstB -
  GPW69_RS04290 phoU 858912..859568 (+) 657 WP_024413748.1 phosphate signaling complex protein PhoU -
  GPW69_RS04295 - 859734..860273 (+) 540 WP_024413749.1 hypothetical protein -
  GPW69_RS04300 ciaR 860467..861138 (+) 672 WP_074391083.1 response regulator transcription factor Regulator
  GPW69_RS04305 ciaH 861131..862510 (+) 1380 WP_024413750.1 sensor histidine kinase Regulator
  GPW69_RS04310 - 862611..863840 (+) 1230 WP_074391082.1 transglutaminase domain-containing protein -
  GPW69_RS04315 rpsT 864104..864352 (-) 249 WP_012027069.1 30S ribosomal protein S20 -
  GPW69_RS04320 coaA 864411..865331 (-) 921 WP_002935283.1 type I pantothenate kinase -
  GPW69_RS04325 - 865440..866030 (+) 591 WP_029188321.1 class I SAM-dependent methyltransferase -
  GPW69_RS04330 - 866027..867304 (+) 1278 WP_002940851.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 459 a.a.        Molecular weight: 51951.52 Da        Isoelectric Point: 6.1945

>NTDB_id=1129595 GPW69_RS04305 WP_024413750.1 861131..862510(+) (ciaH) [Streptococcus suis isolate 9401240]
MPKRIRKLVYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQNSDNTLKRIKEEPAMAVGFAIARTYEPNSVFILQD
SPTSEETTSSSSDSMPVSKDQKNTRDGDQLRLGVNTHVLLYSKSGEMVNPDTFTGLADLPLDKEKLGEIKEATVESSFGM
SEDYRYVTIELATDELGYYSSYDIKYATILVNVSQIKSSIETYESTVAIVMVSAWLISILASIYLSNLSMRPILISYQKQ
KDFVENASHELRTPLAVLQNRLESLFRHPEATILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGLKVDMIDVQPNYFD
EIFANYLMIAEENGKTLTVNNLIHQPIRTDKVLIKQLLTILFDNAMKYTDDDGRIQITANIKDKSVYFTVTDNGLGISDA
DKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKTLGGKISVRDNQPKGTIFEVGLPK

Nucleotide


Download         Length: 1380 bp        

>NTDB_id=1129595 GPW69_RS04305 WP_024413750.1 861131..862510(+) (ciaH) [Streptococcus suis isolate 9401240]
ATGCCTAAGCGAATCAGAAAATTAGTGTATACGGATAAATTTTCCTTCTTTATCCGTTATTTTGCAGTATTTACCCTGAT
TTTTGGCTTGATGACAGCTATCATTTTTCAATTAATGCGTTCAACTATGTATCAAAATTCCGATAATACCTTGAAACGGA
TTAAGGAAGAACCAGCGATGGCTGTTGGTTTTGCAATCGCAAGAACCTATGAGCCCAACTCTGTCTTTATACTTCAAGAT
AGCCCAACTAGTGAAGAAACGACGAGCTCTAGCTCAGATAGCATGCCTGTTTCTAAAGATCAAAAAAATACTAGAGATGG
AGATCAGCTGAGATTAGGTGTCAATACTCATGTCTTACTCTATAGTAAAAGTGGAGAAATGGTCAATCCGGATACTTTTA
CTGGTTTGGCCGACCTACCGTTAGATAAGGAAAAATTGGGCGAAATTAAGGAAGCAACGGTTGAATCAAGCTTCGGTATG
TCTGAAGATTATCGCTATGTGACGATTGAGCTGGCTACAGATGAACTAGGTTATTATTCGTCCTATGATATAAAATATGC
GACAATTTTAGTGAATGTCAGCCAGATAAAATCCTCCATTGAGACCTATGAATCGACAGTTGCTATTGTTATGGTATCAG
CTTGGCTCATTTCTATCTTGGCCAGTATTTACCTATCAAATCTTAGCATGCGTCCAATTCTAATCAGCTATCAAAAACAA
AAGGACTTTGTCGAAAATGCTAGTCATGAGTTGCGTACGCCGCTGGCTGTTCTCCAAAATCGTTTGGAGAGCCTGTTTCG
CCATCCCGAAGCGACGATTTTAGAGAGTAGTGAAAGCATCGGATCTAGTTTGGAAGAAGTTCGAAATATGCGATTATTGA
CAACAAACCTGCTCAATTTGGCTCGTCGTGATGATGGCTTAAAAGTCGATATGATCGATGTCCAACCGAATTATTTTGAT
GAAATCTTTGCTAATTACCTTATGATTGCCGAAGAAAATGGAAAAACACTAACAGTTAATAATTTGATTCATCAGCCGAT
TCGAACAGATAAGGTCCTGATTAAACAGTTACTTACCATTTTATTTGACAATGCCATGAAGTATACCGACGATGATGGCA
GAATTCAAATTACAGCTAATATCAAGGATAAATCTGTCTACTTCACAGTTACCGACAATGGTTTGGGAATCAGCGATGCC
GATAAGAAGAAAATCTTTGATCGCTTTTATCGAGTTGATAAGGCCAGAACACGTCAAAAAGGTGGTTTCGGTCTAGGATT
ATCGTTGGCTCAGCAAATTATTAAGACACTAGGTGGGAAAATCTCTGTTAGAGATAACCAACCGAAAGGAACTATTTTTG
AGGTAGGATTACCTAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(240-306)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(350-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

49.46

100

0.499
  ciaH Streptococcus pneumoniae D39

49.46

100

0.499
  ciaH Streptococcus pneumoniae R6

49.46

100

0.499
  ciaH Streptococcus pneumoniae TIGR4

49.46

100

0.499
  ciaH Streptococcus mutans UA159

49.231

99.129

0.488

Multiple sequence alignment