Detailed information NTG1129585

Bioinformatically predicted

Overview

• Name: comYH
• Type: Machinery gene
• Locus tag: GPW69_RS00780
• Genome accession: NZ_LR738724
• Coordinates: 117726..118679 (+)
• Length: 317 a.a.
• NCBI ID: WP_024414316.1
• Uniprot ID: A0A4T2H6N2
• Organism: Streptococcus suis isolate 9401240
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 112726..123679

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPW69_RS00740	-	112993..113943 (-)	951	WP_074391326.1	S66 peptidase family protein	-
GPW69_RS00745	comYA	114029..114979 (+)	951	WP_074391327.1	competence type IV pilus ATPase ComGA	Machinery gene
GPW69_RS00750	comYB	114891..115928 (+)	1038	WP_269472402.1	competence type IV pilus assembly protein ComGB	Machinery gene
GPW69_RS00755	comYC	115930..116211 (+)	282	WP_074391328.1	competence type IV pilus major pilin ComGC	Machinery gene
GPW69_RS00760	comGD	116192..116599 (+)	408	WP_074391329.1	competence type IV pilus minor pilin ComGD	-
GPW69_RS00765	comYE	116571..116864 (+)	294	WP_024401507.1	competence type IV pilus minor pilin ComGE	Machinery gene
GPW69_RS00770	comGF/cglF	116851..117285 (+)	435	WP_044762030.1	competence type IV pilus minor pilin ComGF	Machinery gene
GPW69_RS00775	comGG	117263..117676 (+)	414	WP_074391330.1	competence type IV pilus minor pilin ComGG	-
GPW69_RS00780	comYH	117726..118679 (+)	954	WP_024414316.1	class I SAM-dependent methyltransferase	Machinery gene
GPW69_RS00785	-	118729..119916 (+)	1188	WP_044680792.1	acetate kinase	-
GPW69_RS00790	-	120233..120784 (+)	552	WP_074391332.1	folate family ECF transporter S component	-
GPW69_RS00795	-	120840..122096 (+)	1257	WP_074391333.1	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	-
GPW69_RS00800	pepA	122141..123202 (-)	1062	WP_074391334.1	glutamyl aminopeptidase	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 35601.70 Da
• Isoelectric Point: 4.4571

>NTDB_id=1129585 GPW69_RS00780 WP_024414316.1 117726..118679(+) (comYH) [Streptococcus suis isolate 9401240]
MNFEKIEQAYDLLLENVQTIQNQLGTNIYDAMIEQNAAYVAGQHETDLVVNNNKTLKQLDLTKEEWRRAFQFLLIKANQT
EPMQYNHQFTPDSIGFILSFLVDQLVSTSKVTVLEIGSGTGNLAQTILNASQKELDYLGIEVDDLLIDLSASIADVMQAD
ISFAQGDAVRPQILKESQVILGDLPIGYYPDDQIASRYQVASPNEHTYAHHLLMEQSLKYLEKDGFAILLAPNDLLTSPQ
SDLLKGWLQEQANIVAMIALPPNLFGKAAMAKSIFVLQKKAARPLAPFVYPLQSLQEPEAIQKFMLNFKNWKQENAI

Nucleotide

• Length: 954 bp

>NTDB_id=1129585 GPW69_RS00780 WP_024414316.1 117726..118679(+) (comYH) [Streptococcus suis isolate 9401240]
ATGAATTTTGAAAAGATCGAACAGGCTTACGACCTGCTATTAGAAAACGTACAGACTATCCAAAACCAGCTAGGCACCAA
TATCTACGATGCCATGATTGAGCAAAATGCTGCTTACGTAGCTGGTCAGCATGAGACAGATCTTGTTGTCAATAATAACA
AGACCTTGAAACAACTAGATTTAACCAAGGAAGAATGGCGTCGTGCCTTCCAATTCCTGCTCATCAAGGCCAATCAGACT
GAACCCATGCAGTATAATCACCAGTTCACACCAGACTCTATCGGATTTATCCTATCTTTTCTAGTGGACCAACTAGTATC
TACTTCCAAGGTGACGGTTCTGGAAATTGGTTCGGGGACAGGCAATCTAGCTCAGACCATTCTCAACGCCAGCCAGAAAG
AATTAGATTACTTGGGGATTGAAGTGGACGACCTCTTGATTGATTTGTCGGCAAGTATTGCGGATGTCATGCAGGCAGAT
ATTTCTTTTGCTCAGGGAGATGCGGTACGTCCGCAGATTTTGAAGGAAAGTCAAGTGATTTTGGGAGATTTGCCTATTGG
CTACTATCCAGATGACCAGATTGCCAGCCGTTATCAGGTTGCCAGCCCAAATGAACATACCTACGCCCATCATTTACTCA
TGGAACAGTCCCTCAAATATCTGGAAAAGGATGGATTCGCTATTCTCTTGGCTCCAAATGATTTGTTGACTAGTCCGCAA
AGCGATTTACTGAAAGGCTGGTTACAGGAGCAAGCCAATATCGTTGCCATGATTGCCCTGCCACCAAATCTCTTTGGGAA
GGCTGCTATGGCCAAGTCTATTTTTGTCTTGCAAAAGAAAGCTGCAAGACCGTTGGCGCCGTTTGTTTATCCCTTACAAA
GTCTTCAAGAACCAGAAGCTATTCAGAAGTTCATGCTCAATTTCAAAAATTGGAAGCAAGAGAATGCAATTTAA

Domains

Predicted by InterproScan.

• N-6 DNA Methylase (N6_Mtase) (69-282)

3D structure

• AlphaFold DB: A0A4T2H6N2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYH	Streptococcus mutans UA140	61.076	99.685	0.609
comYH	Streptococcus mutans UA159	60.759	99.685	0.606