Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   FGK81_RS07945 Genome accession   NZ_LR590466
Coordinates   1548495..1549181 (-) Length   228 a.a.
NCBI ID   WP_138060165.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8193     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1543495..1554181
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK81_RS07925 (NCTC8193_01575) dnaI 1544216..1545118 (-) 903 WP_002991016.1 primosomal protein DnaI -
  FGK81_RS07930 (NCTC8193_01576) - 1545119..1546294 (-) 1176 WP_030127140.1 replication initiation and membrane attachment family protein -
  FGK81_RS07935 (NCTC8193_01577) nrdR 1546278..1546772 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  FGK81_RS07940 (NCTC8193_01578) covS 1546987..1548489 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  FGK81_RS07945 (NCTC8193_01579) covR 1548495..1549181 (-) 687 WP_138060165.1 two-component system response regulator CovR Regulator
  FGK81_RS07950 (NCTC8193_01580) - 1549448..1549981 (-) 534 WP_011889133.1 YceD family protein -
  FGK81_RS07955 (NCTC8193_01581) htpX 1550215..1551111 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  FGK81_RS07960 (NCTC8193_01582) - 1551158..1551715 (-) 558 WP_011889134.1 LemA family protein -
  FGK81_RS07965 (NCTC8193_01583) rsmG 1551865..1552578 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  FGK81_RS07970 (NCTC8193_01584) ktrB 1552663..1554039 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26586.64 Da        Isoelectric Point: 4.6586

>NTDB_id=1126795 FGK81_RS07945 WP_138060165.1 1548495..1549181(-) (covR) [Streptococcus pyogenes strain NCTC8193]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLVLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1126795 FGK81_RS07945 WP_138060165.1 1548495..1549181(-) (covR) [Streptococcus pyogenes strain NCTC8193]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAGTGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGGAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.534

100

0.443
  micA Streptococcus pneumoniae Cp1015

41.739

100

0.421

Multiple sequence alignment