Detailed information NTG1126383

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: E0F40_RS11155
• Genome accession: NZ_LR216065
• Coordinates: 2073161..2073823 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649968.1
• Uniprot ID: A0A098Z9B1
• Organism: Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2068161..2078823

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F40_RS11130 (SAMEA3714487_02120)	-	2068311..2068577 (-)	267	WP_001278167.1	Veg family protein	-
E0F40_RS11135 (SAMEA3714487_02121)	dnaB	2068579..2069931 (-)	1353	WP_000852499.1	replicative DNA helicase	-
E0F40_RS11140 (SAMEA3714487_02122)	rplI	2069975..2070427 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
E0F40_RS11145 (SAMEA3714487_02123)	-	2070424..2072397 (-)	1974	WP_000715124.1	DHH family phosphoesterase	-
E0F40_RS11150 (SAMEA3714487_02124)	hpf	2072533..2073081 (-)	549	WP_000599107.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
E0F40_RS11155 (SAMEA3714487_02125)	comFC/cflB	2073161..2073823 (-)	663	WP_000649968.1	ComF family protein	Machinery gene
E0F40_RS11160 (SAMEA3714487_02126)	comFA/cflA	2073820..2075118 (-)	1299	WP_000867608.1	DEAD/DEAH box helicase	Machinery gene
E0F40_RS11165 (SAMEA3714487_02127)	-	2075174..2075809 (+)	636	WP_000395745.1	YigZ family protein	-
E0F40_RS11170 (SAMEA3714487_02128)	cysK	2076058..2076978 (+)	921	WP_000029860.1	cysteine synthase A	-
E0F40_RS11180 (SAMEA3714487_02129)	-	2077053..2077591 (-)	539	Protein_2087	IS66 family transposase	-
E0F40_RS11185	-	2077564..2077872 (+)	309	Protein_2088	transposase	-
E0F40_RS11190 (SAMEA3714487_02130)	tnpB	2078013..2078336 (-)	324	WP_000973416.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25203.05 Da
• Isoelectric Point: 7.7116

>NTDB_id=1126383 E0F40_RS11155 WP_000649968.1 2073161..2073823(-) (comFC/cflB) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQFWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=1126383 E0F40_RS11155 WP_000649968.1 2073161..2073823(-) (comFC/cflB) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAATTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A098Z9B1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae D39	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae R6	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae TIGR4	99.091	100	0.991
comFC/cflB	Streptococcus mitis SK321	91.364	100	0.914
comFC/cflB	Streptococcus mitis NCTC 12261	90.909	100	0.909