Detailed information NTG1126351

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: E0F40_RS08705
• Genome accession: NZ_LR216065
• Coordinates: 1645202..1645861 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1640202..1650861

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F40_RS08680 (SAMEA3714487_01649)	-	1640507..1640824 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
E0F40_RS08685 (SAMEA3714487_01650)	-	1640839..1641735 (-)	897	WP_000825669.1	PEP phosphonomutase	-
E0F40_RS08690 (SAMEA3714487_01651)	-	1641738..1643000 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
E0F40_RS08695 (SAMEA3714487_01652)	-	1643280..1644458 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
E0F40_RS08700 (SAMEA3714487_01653)	-	1644734..1645132 (-)	399	WP_000155403.1	GNAT family N-acetyltransferase	-
E0F40_RS08705 (SAMEA3714487_01654)	cclA/cilC	1645202..1645861 (+)	660	WP_000565010.1	prepilin peptidase	Machinery gene
E0F40_RS08710 (SAMEA3714487_01655)	-	1645913..1647064 (-)	1152	WP_000481751.1	helix-turn-helix domain-containing protein	-
E0F40_RS08715 (SAMEA3714487_01656)	-	1647079..1647810 (-)	732	Protein_1648	hypothetical protein	-
E0F40_RS11790	-	1648030..1648140 (+)	111	Protein_1649	prepilin peptidase	-
E0F40_RS08725 (SAMEA3714487_01658)	trpA	1648112..1648888 (-)	777	WP_001126993.1	tryptophan synthase subunit alpha	-
E0F40_RS08730 (SAMEA3714487_01659)	trpB	1648881..1650104 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
E0F40_RS08735 (SAMEA3714487_01660)	-	1650082..1650681 (-)	600	WP_000169902.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=1126351 E0F40_RS08705 WP_000565010.1 1645202..1645861(+) (cclA/cilC) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=1126351 E0F40_RS08705 WP_000565010.1 1645202..1645861(+) (cclA/cilC) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877