Detailed information NTG1126276

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: E0F31_RS08735
• Genome accession: NZ_LR216064
• Coordinates: 1637193..1637852 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1632193..1642852

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F31_RS08715 (SAMEA3714520_01639)	-	1632830..1633726 (-)	897	WP_000825665.1	PEP phosphonomutase	-
E0F31_RS08720 (SAMEA3714520_01640)	-	1633729..1634991 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
E0F31_RS08725 (SAMEA3714520_01641)	-	1635271..1636449 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
E0F31_RS08730 (SAMEA3714520_01642)	-	1636677..1637123 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
E0F31_RS08735 (SAMEA3714520_01643)	cclA/cilC	1637193..1637852 (+)	660	WP_000565017.1	prepilin peptidase	Machinery gene
E0F31_RS08740 (SAMEA3714520_01644)	-	1637904..1639055 (-)	1152	WP_000481760.1	XRE family transcriptional regulator	-
E0F31_RS08745 (SAMEA3714520_01645)	-	1639070..1639801 (-)	732	WP_000934017.1	hypothetical protein	-
E0F31_RS11485	-	1640021..1640131 (+)	111	Protein_1671	prepilin peptidase	-
E0F31_RS08755 (SAMEA3714520_01646)	trpA	1640103..1640879 (-)	777	WP_054374565.1	tryptophan synthase subunit alpha	-
E0F31_RS08760 (SAMEA3714520_01647)	trpB	1640872..1642095 (-)	1224	WP_054363266.1	tryptophan synthase subunit beta	-
E0F31_RS08765 (SAMEA3714520_01648)	-	1642073..1642672 (-)	600	WP_054363267.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=1126276 E0F31_RS08735 WP_000565017.1 1637193..1637852(+) (cclA/cilC) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=1126276 E0F31_RS08735 WP_000565017.1 1637193..1637852(+) (cclA/cilC) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858