Detailed information NTG1126224

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: E0F39_RS10895
• Genome accession: NZ_LR216060
• Coordinates: 1999563..2000270 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166471.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain GPSC47 substr. ST315
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1998451..1998840	1999563..2000270	flank	723

Gene organization within MGE regions

Location: 1998451..2000270

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F39_RS10885 (SAMEA3713867_02060)	-	1998451..1999008 (-)	558	Protein_2048	transposase family protein	-
E0F39_RS10890 (SAMEA3713867_02061)	-	1998994..1999479 (+)	486	WP_000035500.1	cupin domain-containing protein	-
E0F39_RS10895 (SAMEA3713867_02062)	vicR	1999563..2000270 (+)	708	WP_000166471.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27212.58 Da
• Isoelectric Point: 6.6568

>NTDB_id=1126224 E0F39_RS10895 WP_000166471.1 1999563..2000270(+) (vicR) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=1126224 E0F39_RS10895 WP_000166471.1 1999563..2000270(+) (vicR) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTGACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

• Response regulator receiver domain (Response_reg) (5-115)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	40.773	99.149	0.404
covR	Streptococcus salivarius strain HSISS4	39.744	99.574	0.396