Detailed information NTG1126199

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: E0F39_RS09370
• Genome accession: NZ_LR216060
• Coordinates: 1741926..1742585 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565001.1
• Uniprot ID: A0A0B7M7B9
• Organism: Streptococcus pneumoniae strain GPSC47 substr. ST315
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1736926..1747585

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F39_RS09345 (SAMEA3713867_01766)	-	1737231..1737548 (-)	318	WP_001865113.1	PTS sugar transporter subunit IIB	-
E0F39_RS09350 (SAMEA3713867_01767)	-	1737563..1738459 (-)	897	WP_001865114.1	hypothetical protein	-
E0F39_RS09355 (SAMEA3713867_01768)	-	1738462..1739724 (-)	1263	WP_000413342.1	PTS sugar transporter subunit IIC	-
E0F39_RS09360 (SAMEA3713867_01769)	-	1740004..1741182 (+)	1179	WP_001865373.1	ROK family transcriptional regulator	-
E0F39_RS09365 (SAMEA3713867_01770)	-	1741410..1741856 (-)	447	WP_000155432.1	GNAT family N-acetyltransferase	-
E0F39_RS09370 (SAMEA3713867_01771)	cclA/cilC	1741926..1742585 (+)	660	WP_000565001.1	prepilin peptidase	Machinery gene
E0F39_RS09375 (SAMEA3713867_01772)	-	1742637..1743788 (-)	1152	WP_001865397.1	XRE family transcriptional regulator	-
E0F39_RS09380 (SAMEA3713867_01773)	-	1743803..1744534 (-)	732	WP_000934016.1	hypothetical protein	-
E0F39_RS12385	-	1744754..1744864 (+)	111	Protein_1796	prepilin peptidase	-
E0F39_RS09390 (SAMEA3713867_01774)	trpA	1744836..1745612 (-)	777	WP_001127027.1	tryptophan synthase subunit alpha	-
E0F39_RS09395 (SAMEA3713867_01775)	trpB	1745605..1746828 (-)	1224	WP_001865226.1	tryptophan synthase subunit beta	-
E0F39_RS09400 (SAMEA3713867_01776)	-	1746806..1747405 (-)	600	WP_001865225.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24820.92 Da
• Isoelectric Point: 7.2761

>NTDB_id=1126199 E0F39_RS09370 WP_000565001.1 1741926..1742585(+) (cclA/cilC) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=1126199 E0F39_RS09370 WP_000565001.1 1741926..1742585(+) (cclA/cilC) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M7B9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	98.174	100	0.982
cclA/cilC	Streptococcus pneumoniae Rx1	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae D39	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae R6	96.804	100	0.968
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872