Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   EL254_RS00410 Genome accession   NZ_LR134512
Coordinates   63737..64648 (+) Length   303 a.a.
NCBI ID   WP_000912100.1    Uniprot ID   A0A0E1EEL0
Organism   Streptococcus agalactiae strain NCTC13949     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 58737..69648
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL254_RS00390 (NCTC13949_00076) purE 59250..59738 (+) 489 WP_001182532.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  EL254_RS00395 (NCTC13949_00077) purK 59725..60816 (+) 1092 WP_001084005.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  EL254_RS00400 (NCTC13949_00078) - 60870..62261 (+) 1392 WP_001079802.1 hypothetical protein -
  EL254_RS00405 (NCTC13949_00079) purB 62286..63584 (+) 1299 WP_000572887.1 adenylosuccinate lyase -
  EL254_RS00410 (NCTC13949_00080) comR 63737..64648 (+) 912 WP_000912100.1 helix-turn-helix domain-containing protein Regulator
  EL254_RS00415 (NCTC13949_00081) ruvB 64945..65943 (+) 999 WP_000196633.1 Holliday junction branch migration DNA helicase RuvB -
  EL254_RS00420 (NCTC13949_00082) - 66095..66532 (+) 438 WP_000754813.1 low molecular weight protein-tyrosine-phosphatase -
  EL254_RS00425 (NCTC13949_00083) - 66539..66919 (+) 381 WP_000787700.1 membrane protein -
  EL254_RS00430 (NCTC13949_00084) - 66916..68694 (+) 1779 WP_001220909.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35654.11 Da        Isoelectric Point: 5.6370

>NTDB_id=1123598 EL254_RS00410 WP_000912100.1 63737..64648(+) (comR) [Streptococcus agalactiae strain NCTC13949]
MLKHFGSKVRNLRVTRNITREDFCGDETELSVRQLARIESGQSIPNLTKAHYIAKQLNVKLDILTGGESLELPKRYKELK
YLILRIPTYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLND
LIIIDLFLTCAVVSKFNNRAFTKEVFQTICKTLISQNHKLTAEDLFWFNHVLLNCVFVGLCLNSEECLAEMLEVSRQTMV
STHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEWQEDITGH

Nucleotide


Download         Length: 912 bp        

>NTDB_id=1123598 EL254_RS00410 WP_000912100.1 63737..64648(+) (comR) [Streptococcus agalactiae strain NCTC13949]
ATGTTAAAACATTTTGGTAGTAAAGTAAGAAATTTGAGAGTAACTAGAAATATTACTCGCGAAGATTTTTGTGGTGATGA
AACTGAGTTATCTGTAAGACAATTAGCTAGGATTGAAAGTGGACAGTCAATTCCAAACTTGACTAAAGCTCACTACATAG
CTAAACAATTGAATGTAAAATTGGATATTTTAACAGGAGGAGAGAGCTTAGAATTACCTAAACGGTATAAAGAGTTGAAG
TATTTGATTTTAAGAATTCCAACTTATGCAGATGCTGAACGATTAAAATTAAGAGAATGTCAGTTTGATCATATTTTCGA
AGAATTCTATGATAATCTTCCAGAAGACGAGTGCTTAGCAATTGACAGTTTACAAGCTAAATTTGAAGTCTATCAAACAG
GAGACATTAATTTTGGTGTGGAGGTTTTATGCGAATGCTTTGATAAAGTAAAATATAAAGAAAAATATACTCTTAATGAT
TTGATTATCATAGATTTGTTTTTAACTTGTGCAGTTGTATCTAAATTTAACAATAGAGCATTTACTAAAGAAGTATTTCA
AACTATATGTAAAACTTTGATAAGTCAGAACCACAAACTTACAGCAGAAGATTTGTTTTGGTTTAATCATGTACTCCTGA
ATTGTGTATTTGTTGGACTTTGTTTAAATAGTGAAGAGTGTCTTGCAGAAATGTTAGAAGTTAGCCGACAAACGATGGTG
TCAACACATGATTTTCATAAAATGCCTTTATATTTTATGTACCAATGGAAATACTTCATTACAATTGACAATGATATAAA
GTCTGCAGAAAATGCTTACCAACAATCAATTATGTTTTCAAAAATGATTGATGACAAGCATCTAATTAAAAAATTAGAAT
TGGAGTGGCAAGAAGATATAACAGGACATTGA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(10-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E1EEL0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS315

52.667

99.01

0.521
  comR Streptococcus mutans UA159

44.816

98.68

0.442
  comR Streptococcus pyogenes MGAS8232

42.904

100

0.429
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

44.33

96.04

0.426

Multiple sequence alignment