Detailed information
Bioinformatically predicted
Overview
| Name | comW | Type | Regulator |
| Locus tag | EL096_RS08800 | Genome accession | NZ_LR134294 |
| Coordinates | 1645758..1645994 (+) | Length | 78 a.a. |
| NCBI ID | WP_000939545.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae strain NCTC12977 | ||
| Function | stabilization and activation of ComX (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1635295..1713854 | 1645758..1645994 | within | 0 |
| IS/Tn | 1645235..1645441 | 1645758..1645994 | flank | 317 |
Gene organization within MGE regions
Location: 1635295..1713854
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL096_RS08750 (NCTC12977_01705) | ftsH | 1635295..1637253 (+) | 1959 | WP_000744557.1 | ATP-dependent zinc metalloprotease FtsH | - |
| EL096_RS08755 (NCTC12977_01706) | - | 1637318..1638565 (-) | 1248 | WP_114880800.1 | ISL3 family transposase | - |
| EL096_RS08760 (NCTC12977_01707) | comX/comX2 | 1638789..1639268 (+) | 480 | WP_000588874.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| EL096_RS08795 | - | 1644695..1645492 (-) | 798 | Protein_1624 | transposase | - |
| EL096_RS08800 (NCTC12977_01715) | comW | 1645758..1645994 (+) | 237 | WP_000939545.1 | sigma(X)-activator ComW | Regulator |
| EL096_RS08805 (NCTC12977_01716) | - | 1646225..1647511 (+) | 1287 | WP_000205044.1 | adenylosuccinate synthase | - |
| EL096_RS08810 (NCTC12977_01717) | - | 1647753..1648901 (-) | 1149 | WP_000876732.1 | tyrosine-type recombinase/integrase | - |
| EL096_RS08820 (NCTC12977_01718) | - | 1649087..1650010 (-) | 924 | WP_000122591.1 | exonuclease domain-containing protein | - |
| EL096_RS08825 (NCTC12977_01719) | - | 1650023..1650406 (-) | 384 | WP_001865140.1 | ImmA/IrrE family metallo-endopeptidase | - |
| EL096_RS08830 (NCTC12977_01720) | - | 1650419..1650784 (-) | 366 | WP_000492031.1 | helix-turn-helix domain-containing protein | - |
| EL096_RS08835 (NCTC12977_01721) | - | 1651090..1651572 (-) | 483 | WP_000842471.1 | hypothetical protein | - |
| EL096_RS08840 (NCTC12977_01722) | - | 1651627..1651830 (+) | 204 | WP_000032096.1 | hypothetical protein | - |
| EL096_RS08845 (NCTC12977_01723) | - | 1651847..1652044 (+) | 198 | WP_001057654.1 | hypothetical protein | - |
| EL096_RS08850 (NCTC12977_01725) | - | 1652160..1652819 (-) | 660 | WP_001865135.1 | hypothetical protein | - |
| EL096_RS08855 (NCTC12977_01726) | - | 1652873..1653589 (+) | 717 | WP_001865134.1 | ORF6C domain-containing protein | - |
| EL096_RS08860 (NCTC12977_01727) | - | 1653602..1653859 (+) | 258 | WP_000370959.1 | hypothetical protein | - |
| EL096_RS08865 (NCTC12977_01728) | - | 1653945..1654265 (+) | 321 | WP_000462826.1 | hypothetical protein | - |
| EL096_RS08870 (NCTC12977_01729) | - | 1654281..1654577 (+) | 297 | WP_001865133.1 | hypothetical protein | - |
| EL096_RS08875 (NCTC12977_01730) | - | 1654570..1655376 (+) | 807 | WP_054387342.1 | phage replisome organizer N-terminal domain-containing protein | - |
| EL096_RS08880 (NCTC12977_01732) | - | 1655516..1656286 (+) | 771 | WP_000228214.1 | ATP-binding protein | - |
| EL096_RS12145 (NCTC12977_01733) | - | 1656301..1656495 (+) | 195 | WP_000470305.1 | hypothetical protein | - |
| EL096_RS08890 (NCTC12977_01734) | - | 1656495..1656722 (+) | 228 | WP_050267377.1 | hypothetical protein | - |
| EL096_RS08895 (NCTC12977_01736) | - | 1656849..1657016 (+) | 168 | WP_000233203.1 | hypothetical protein | - |
| EL096_RS08905 (NCTC12977_01737) | - | 1657344..1657697 (+) | 354 | WP_001177094.1 | helix-turn-helix domain-containing protein | - |
| EL096_RS08910 (NCTC12977_01738) | - | 1657679..1658143 (+) | 465 | WP_000516820.1 | hypothetical protein | - |
| EL096_RS08915 (NCTC12977_01739) | - | 1658252..1658794 (+) | 543 | WP_001028147.1 | site-specific integrase | - |
| EL096_RS08920 | - | 1659335..1659541 (+) | 207 | WP_223842409.1 | HNH endonuclease | - |
| EL096_RS08925 (NCTC12977_01740) | - | 1659678..1660172 (+) | 495 | WP_054387340.1 | hypothetical protein | - |
| EL096_RS08930 (NCTC12977_01741) | - | 1660165..1661877 (+) | 1713 | WP_000230006.1 | terminase TerL endonuclease subunit | - |
| EL096_RS08935 (NCTC12977_01742) | - | 1661886..1663028 (+) | 1143 | WP_001812652.1 | phage portal protein | - |
| EL096_RS08940 (NCTC12977_01743) | - | 1663075..1663617 (+) | 543 | WP_000413203.1 | HK97 family phage prohead protease | - |
| EL096_RS08945 (NCTC12977_01744) | - | 1663632..1664885 (+) | 1254 | WP_000855224.1 | phage major capsid protein | - |
| EL096_RS08950 (NCTC12977_01745) | - | 1664911..1665246 (+) | 336 | WP_000154006.1 | hypothetical protein | - |
| EL096_RS08955 (NCTC12977_01746) | - | 1665243..1665548 (+) | 306 | WP_000842790.1 | head-tail adaptor protein | - |
| EL096_RS08960 (NCTC12977_01747) | - | 1665548..1665895 (+) | 348 | WP_001074487.1 | hypothetical protein | - |
| EL096_RS08965 (NCTC12977_01748) | - | 1665882..1666226 (+) | 345 | WP_000534621.1 | hypothetical protein | - |
| EL096_RS08970 (NCTC12977_01749) | - | 1666240..1666908 (+) | 669 | WP_000221469.1 | hypothetical protein | - |
| EL096_RS08975 (NCTC12977_01750) | - | 1666910..1667386 (+) | 477 | WP_000591561.1 | hypothetical protein | - |
| EL096_RS08985 (NCTC12977_01751) | - | 1667573..1670311 (+) | 2739 | WP_000852167.1 | phage tail tape measure protein | - |
| EL096_RS08990 (NCTC12977_01752) | - | 1670308..1671030 (+) | 723 | WP_050199190.1 | phage tail protein | - |
| EL096_RS08995 (NCTC12977_01753) | - | 1671031..1678992 (+) | 7962 | WP_114880801.1 | phage tail spike protein | - |
| EL096_RS12150 (NCTC12977_01754) | - | 1678989..1679105 (+) | 117 | WP_001063633.1 | hypothetical protein | - |
| EL096_RS09005 (NCTC12977_01755) | - | 1679086..1679289 (+) | 204 | WP_001091109.1 | hypothetical protein | - |
| EL096_RS09010 (NCTC12977_01756) | - | 1679292..1679642 (+) | 351 | WP_000852248.1 | hypothetical protein | - |
| EL096_RS09015 (NCTC12977_01757) | - | 1679652..1680068 (+) | 417 | WP_001165341.1 | phage holin family protein | - |
| EL096_RS09020 (NCTC12977_01758) | - | 1680072..1680404 (+) | 333 | WP_001186207.1 | phage holin | - |
| EL096_RS09025 (NCTC12977_01759) | lytA | 1680408..1681364 (+) | 957 | WP_000350489.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| EL096_RS09030 (NCTC12977_01760) | - | 1681633..1681812 (-) | 180 | WP_001233269.1 | hypothetical protein | - |
| EL096_RS11540 (NCTC12977_01761) | - | 1681954..1682103 (-) | 150 | WP_162489709.1 | hypothetical protein | - |
| EL096_RS09035 (NCTC12977_01762) | tadA | 1682373..1682840 (+) | 468 | WP_000291874.1 | tRNA adenosine(34) deaminase TadA | - |
| EL096_RS09045 (NCTC12977_01764) | - | 1683027..1683470 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| EL096_RS09050 (NCTC12977_01765) | - | 1683472..1683987 (+) | 516 | WP_000691236.1 | histidine phosphatase family protein | - |
| EL096_RS09055 (NCTC12977_01766) | radA | 1684001..1685362 (+) | 1362 | WP_074017595.1 | DNA repair protein RadA | Machinery gene |
| EL096_RS09060 (NCTC12977_01767) | - | 1685435..1685932 (+) | 498 | WP_001809263.1 | beta-class carbonic anhydrase | - |
| EL096_RS09070 (NCTC12977_01768) | - | 1685957..1686771 (+) | 815 | Protein_1675 | PrsW family intramembrane metalloprotease | - |
| EL096_RS09075 (NCTC12977_01769) | - | 1686916..1687884 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| EL096_RS11915 | - | 1688002..1688947 (+) | 946 | Protein_1677 | Rpn family recombination-promoting nuclease/putative transposase | - |
| EL096_RS09095 (NCTC12977_01772) | polA | 1689450..1692083 (+) | 2634 | WP_050279195.1 | DNA polymerase I | - |
| EL096_RS09100 (NCTC12977_01773) | - | 1692168..1692605 (+) | 438 | WP_000076479.1 | CoA-binding protein | - |
| EL096_RS11920 (NCTC12977_01774) | - | 1692646..1692984 (+) | 339 | WP_061849647.1 | hypothetical protein | - |
| EL096_RS09110 (NCTC12977_01775) | - | 1693013..1694023 (-) | 1011 | WP_000009175.1 | YeiH family protein | - |
| EL096_RS09115 (NCTC12977_01776) | - | 1694172..1695341 (+) | 1170 | WP_000366348.1 | pyridoxal phosphate-dependent aminotransferase | - |
| EL096_RS09120 (NCTC12977_01777) | recO | 1695338..1696108 (+) | 771 | WP_050220959.1 | DNA repair protein RecO | - |
| EL096_RS09125 (NCTC12977_01778) | plsX | 1696105..1697097 (+) | 993 | WP_000717456.1 | phosphate acyltransferase PlsX | - |
| EL096_RS09130 (NCTC12977_01779) | - | 1697103..1697336 (+) | 234 | WP_000136447.1 | acyl carrier protein | - |
| EL096_RS09135 (NCTC12977_01780) | - | 1697373..1697672 (+) | 300 | Protein_1686 | transposase family protein | - |
| EL096_RS09140 (NCTC12977_01781) | blpU | 1697875..1698105 (+) | 231 | WP_001093487.1 | bacteriocin-like peptide BlpU | - |
| EL096_RS12065 | - | 1698108..1698233 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| EL096_RS09145 | - | 1698483..1699800 (-) | 1318 | Protein_1689 | ISL3 family transposase | - |
| EL096_RS09150 (NCTC12977_01785) | comA | 1700234..1702387 (+) | 2154 | WP_050221223.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| EL096_RS09155 (NCTC12977_01786) | comB | 1702400..1703749 (+) | 1350 | WP_000801629.1 | competence pheromone export protein ComB | Regulator |
| EL096_RS09160 (NCTC12977_01787) | purC | 1703919..1704626 (+) | 708 | WP_000043313.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| EL096_RS12155 | - | 1704637..1704771 (+) | 135 | WP_000429436.1 | hypothetical protein | - |
| EL096_RS09170 (NCTC12977_01788) | - | 1704828..1708553 (+) | 3726 | WP_114880802.1 | phosphoribosylformylglycinamidine synthase | - |
| EL096_RS09175 (NCTC12977_01789) | purF | 1708646..1710088 (+) | 1443 | WP_050104961.1 | amidophosphoribosyltransferase | - |
| EL096_RS09180 (NCTC12977_01790) | purM | 1710125..1711147 (+) | 1023 | WP_114880803.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| EL096_RS09185 (NCTC12977_01791) | purN | 1711144..1711689 (+) | 546 | WP_000717506.1 | phosphoribosylglycinamide formyltransferase | - |
| EL096_RS09190 (NCTC12977_01792) | - | 1711773..1712282 (+) | 510 | WP_050104960.1 | VanZ family protein | - |
| EL096_RS09195 (NCTC12977_01793) | purH | 1712307..1713854 (+) | 1548 | WP_114880804.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 78 a.a. Molecular weight: 9658.13 Da Isoelectric Point: 6.7051
>NTDB_id=1120589 EL096_RS08800 WP_000939545.1 1645758..1645994(+) (comW) [Streptococcus pneumoniae strain NCTC12977]
MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVRYGIGCRKDFIVYHYRVAYRLYLEKLVMNRGFISC
MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVRYGIGCRKDFIVYHYRVAYRLYLEKLVMNRGFISC
Nucleotide
Download Length: 237 bp
>NTDB_id=1120589 EL096_RS08800 WP_000939545.1 1645758..1645994(+) (comW) [Streptococcus pneumoniae strain NCTC12977]
ATGTTACAAAAAATTTATGAGCAGATGGCTAATTTCTATGATAGTATTGAAGAAGAGTATGGTCCTACATTTGGTGATAA
TTTTGACTGGGAACATGTTCATTTTAAATTTTTAATTTATTATTTAGTGAGATATGGCATTGGTTGTCGTAAGGATTTTA
TCGTTTACCATTATCGTGTTGCTTATCGTTTGTATCTTGAAAAATTGGTAATGAATCGGGGTTTTATTTCTTGTTGA
ATGTTACAAAAAATTTATGAGCAGATGGCTAATTTCTATGATAGTATTGAAGAAGAGTATGGTCCTACATTTGGTGATAA
TTTTGACTGGGAACATGTTCATTTTAAATTTTTAATTTATTATTTAGTGAGATATGGCATTGGTTGTCGTAAGGATTTTA
TCGTTTACCATTATCGTGTTGCTTATCGTTTGTATCTTGAAAAATTGGTAATGAATCGGGGTTTTATTTCTTGTTGA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comW | Streptococcus pneumoniae Rx1 |
100 |
100 |
1 |
| comW | Streptococcus pneumoniae D39 |
100 |
100 |
1 |
| comW | Streptococcus pneumoniae R6 |
100 |
100 |
1 |
| comW | Streptococcus pneumoniae TIGR4 |
100 |
100 |
1 |
| comW | Streptococcus mitis SK321 |
75.641 |
100 |
0.756 |
| comW | Streptococcus mitis NCTC 12261 |
75.325 |
98.718 |
0.744 |